AI Article Synopsis
- The study utilizes flow chemistry to create and transfer reactive intermediates for enhanced reactions.
- The authors demonstrate a room temperature coupling between boronic acids and diazo compounds generated from hydrazones.
- Manganese oxide (MnO) is used as the oxidant in this process, emphasizing the efficiency of flow conditions in chemical reactions.
Article Abstract
The work takes advantage of an important feature of flow chemistry, whereby the generation of a transient species (or reactive intermediate) can be followed by a transfer step into another chemical environment, before the intermediate is reacted with a coupling partner. This concept is successfully applied to achieve a room temperature sp-sp cross coupling of boronic acids with diazo compounds, these latter species being generated from hydrazones under flow conditions using MnO as the oxidant.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811102 | PMC |
| http://dx.doi.org/10.1039/c4sc03072a | DOI Listing |
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