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Analysis of results of radiotherapy for oropharyngeal cancer.
Physiol Int
November 2024
2Centre of Radiotherapy, National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.
Article Synopsis
- Smoking and alcohol are major risk factors for oropharyngeal tumors, but there's a rise in HPV-related cases in younger patients; radiotherapy plays a crucial role in treatment.
- A study of 95 patients treated with radio- or radio-chemotherapy showed that HPV positive tumors had better local control and survival rates compared to HPV negative tumors, with smoking adversely affecting outcomes.
- The results suggest that treatment involving chemotherapy and radiation enhances survival for HPV-negative tumors more effectively, whereas the benefits are less pronounced for HPV positive tumors, highlighting the negative impact of smoking on response to treatment.
A population-based study using nomograms to predict overall and cancer-specific survival in HPV-associated CSCC.
Cancer Sci
November 2024
Department of Dermatology, The First Affiliated Hospital of Jinan University and Jinan University Institute of Dermatology, Guangzhou, China.
Article Synopsis
- The study aimed to create and validate nomograms to predict overall survival (OS) and cancer-specific survival (CSS) in patients with cutaneous squamous cell carcinoma (CSCC) linked to human papillomavirus (HPV) infection.
- Researchers analyzed data from 2,238 patients using multiple statistical models to identify significant risk factors and categorize patients into low, intermediate, and high-risk groups.
- The effectiveness of the nomograms was demonstrated through metrics like the C index and decision curve analysis, showing their potential as valuable tools for clinicians in discussing patient prognoses over the next few years.
Review effects of radiation treatment on HPV-related vulvar cancer: a meta-analysis and systematic review.
Front Oncol
September 2024
Department of Radiation Oncology, The Third People's Hospital of Dalian, Dalian Municipal Cancer Hospital, Affiliated Dalian Third People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
Objective: Vulvar carcinoma exhibits a robust correlation alongside HPV infection; however, the impact of HPV rank on the prognostic outcomes of radiation therapy within vulvar malignancies stays ambiguous. In the present study, we performed a comprehensive examination as well as meta-analysis to assess the influence of infection with HPV upon the long-term outlook as well as sensitivity of individuals with vulvar cancer undergoing radiation therapy.
Methods: A meticulous examination of the existing research was conducted in accordance with the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
Impact of Surveillance Imaging in Patients With HPV-Associated Oropharyngeal Carcinoma Treated With Definitive Radiation and Chemotherapy.
Am J Clin Oncol
January 2025
Departments of Radiation Oncology.
Objectives: Surveillance imaging for HPV-associated oropharyngeal carcinomas (OPCs) differs among physicians and institutions. Surveillance imaging can detect disease progression earlier, but can also contribute to anxiety and cost, without proven survival benefits. We sought to determine practice patterns of surveillance imaging and the number of surveillance scans needed to detect one recurrence in patients with HPV-associated OPCs.
View Article and Find Full Text PDFTrends in the treatment of human papillomavirus-associated oropharyngeal carcinoma in Slovakia.
Neoplasma
August 2024
Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
The optimal treatment of oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) is currently a subject of clinical research. This questionnaire study investigated current trends in the treatment of HPV-associated (HPV+) OPC in Slovakia with the incorporation of deintensification of oncological treatment into routine clinical practice outside of clinical trials. The Slovak Cooperative Head and Neck Cancer Group (SCHNCG) developed a questionnaire aimed at identifying trends in the oncological treatment of HPV+ OPC intended for all radiation oncology (RO) facilities in Slovakia.
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