AI Article Synopsis
- TP-6076 is a synthetic antibiotic that targets bacterial protein synthesis, specifically tested against carbapenem-resistant Acinetobacter baumannii from 13 Greek hospitals.
- The study involved 121 bacterial isolates, where TP-6076 showed low minimum inhibitory concentrations (MICs) of 0.03 mg/L and 0.06 mg/L, indicating strong effectiveness.
- Compared to other antibiotics like tigecycline and minocycline, TP-6076 demonstrated superior activity against resistant strains, while its effectiveness remained consistent regardless of colistin susceptibility.
Article Abstract
TP-6076 is a synthetic fluorocycline antibiotic that inhibits bacterial protein synthesis. In this study, carbapenem-resistant Acinetobacter baumannii clinical isolates from 13 Greek hospitals were tested for susceptibility to TP-6076 and comparator antibiotics. Broth microdilution plates were used to determine minimum inhibitory concentrations (MICs). A total of 121 non-duplicate A. baumannii isolates were tested. The MIC and MIC values of TP-6076 were 0.03 mg/L and 0.06 mg/L, respectively. Tigecycline was the second most active antibiotic (MIC, 2 mg/L), followed by minocycline (MIC, 8 mg/L). TP-6076 exhibited MIC values that were one dilution lower against tigecycline- and minocycline-susceptible isolates than against resistant isolates. There was no difference in the MIC value for colistin-susceptible or -resistant isolates. In conclusion, TP-6076 exhibited greater antimicrobial activity in vitro against carbapenem-resistant A. baumannii than comparator antibiotics.
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| http://dx.doi.org/10.1016/j.ijantimicag.2018.03.009 | DOI Listing |
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