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Association between triglyceride-glucose index and cardiovascular disease in US adults with chronic kidney disease: a population-based study.
BMC Cardiovasc Disord
December 2024
Department of Nephrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Objectives: Triglyceride-glucose (TyG) index, which is a valuable measure of insulin resistance, has been found to have predictive value for cardiovascular disease (CVD). However, its relationship with CVD among individuals with chronic kidney disease (CKD) has not been thoroughly investigated. This study focused on examining the relationship of the TyG index and CVD among CKD patients in United States.
View Article and Find Full Text PDFRacial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients.
J Hypertens
November 2024
Non-Profit Research Association Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium.
Objectives: Greater vulnerability of Black vs. White individuals to cardiovascular disease (CVD) and chronic kidney disease (CKD) is well charted in the United States, but studies involving sub-Saharan blacks are scarce.
Methods: Baseline data (2021-2024) were collected in 168 sub-Saharan Blacks and 93 European Whites in an ongoing clinical trial (NCT04299529), using standardized patient selection criteria.
Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine.
Cureus
October 2024
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Article Synopsis
- - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
- - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
- - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
Detection of infective endocarditis with [Cu]Cu-DOTATATE positron emission tomography/computed tomography: a case series.
Eur Heart J Case Rep
September 2024
Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, 2100 Copenhagen, Denmark.
Article Synopsis
- Infective endocarditis (IE) is a severe condition that can be fatal, particularly in patients with prosthetic valves. The study evaluates the effectiveness of a new PET tracer, [Cu]Cu-DOTATATE, for diagnosing IE.
- The case series highlights two patients: Patient 1, with a mitral valve prosthesis, showed positive tracer uptake at the infection site and had a successful surgery, while Patient 2, with an aortic valve infection, showed no uptake and experienced complications leading to death.
- This research suggests the potential diagnostic value of [Cu]Cu-DOTATATE for IE but also indicates variability in its effectiveness based on the type of valve involved.
Trimethylamine -Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community-Based Populations.
Circ Heart Fail
August 2024
Department of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.
Background: Growing evidence indicates that trimethylamine -oxide, a gut microbial metabolite of dietary choline and carnitine, promotes both cardiovascular disease and chronic kidney disease risk. It remains unclear how circulating concentrations of trimethylamine -oxide and its related dietary and gut microbe-derived metabolites (choline, betaine, carnitine, γ-butyrobetaine, and crotonobetaine) affect incident heart failure (HF).
Methods: We evaluated 11 768 participants from the Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis with serial measures of metabolites.
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