AI Article Synopsis
- The study introduces nucleophilic imines along with 2-hydroxybenzophenone to enhance chemical reactions.
- A key aspect of this approach is the formation of a six-membered ring through hydrogen bonding, which boosts reactivity and selectivity.
- The effectiveness of this strategy is backed by both computational DFT calculations and experimental evidence.
Article Abstract
The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials.
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| http://dx.doi.org/10.1039/C8CC01479E | DOI Listing |
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