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| http://dx.doi.org/10.18632/oncoscience.396 | DOI Listing |
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Re-thinking osteoarthritis pathogenesis: what can we learn (and what do we need to unlearn) from mouse models about the mechanisms involved in disease development.
Arthritis Res Ther
April 2023
Department of Medicine, Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.
Article Synopsis
- Efforts to create disease-modifying drugs for osteoarthritis have struggled due to the failure of promising candidates in clinical trials, highlighting a need to re-examine the pathology of the disease.
- Significant differences exist in the pathways of osteoarthritis between mouse models (like STR/ort and injury-induced) and humans, emphasizing the complexity and heterogeneity in how the disease manifests.
- Key signaling pathways, such as Wnt and TGF-β, vary between species; for example, TGF-β signaling in mice is primarily through TGF-β3, while in humans it operates through TGF-β1, indicating potential discrepancies in treatment approaches.
Re-thinking therapeutic development for CNS metastatic disease.
Exp Dermatol
January 2022
Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
There has been unprecedented progress in the development of systemic therapies for patients with metastatic melanoma over the last decade. There is now tremendous potential and momentum to further and markedly reduce the impact of this disease. However, developing more effective treatments for metastases to the CNS remains a critical challenge for patients with melanoma.
View Article and Find Full Text PDFElectrophysiological features in acromegaly: re-thinking the arrhythmic risk?
J Endocrinol Invest
February 2021
Department of Medicine (DIMED), University of Padua, Clinica Medica 3, via Giustiniani 2, 35128, Padova, Italy.
Background: Acromegaly is disease associated with a specific cardiomyopathy. Hitherto, it has been widely understood that acromegaly carries an increased risk of arrhythmia.
Purpose: In this review we show that evidences are limited to a small number of case-control studies that reported increased rates of premature ventricular beats (PVB) but no more significant arrhythmia.
Re-thinking preclinical models of cancer metastasis.
Oncoscience
September 2018
Department of Regenerative and Cancer Cell Biology, Albany Medical College, Bldg. Medical Sciences (MS), Albany, NY 12208, USA.
Re-thinking the preclinical development of GBM therapeutics.
Oncoscience
January 2018
Department of Internal Medicine Specialities, Centre of Translational Onco-Hematology, Medical School, University of Geneva, Geneva, Switzerland.
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