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| http://dx.doi.org/10.1016/j.eucr.2018.03.005 | DOI Listing |
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Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization.
Neoplasia
September 2023
Department of Urology, Huashan Hospital Fudan University, No. 12 Middle Wulumuqi Road, Shanghai 200040, China. Electronic address:
We have previously demonstrated abnormal gut microbial composition in castration-resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut microbiota-derived short-chain fatty acids (SCFAs) as a mediator linking CRPC microbiota dysbiosis and prostate cancer (PCa) progression. By using transgenic TRAMP mouse model, PCa patient samples, in vitro PCa cell transwell and macrophage recruitment assays, we examined the effects of CRPC fecal microbiota transplantation (FMT) and SCFAs on PCa progression. Our results showed that FMT with CRPC patients' fecal suspension increased SCFAs-producing gut microbiotas such as Ruminococcus, Alistipes, Phascolarctobaterium in TRAMP mice, and correspondingly raised their gut SCFAs (acetate and butyrate) levels.
View Article and Find Full Text PDFPresence and Relevance of Emerging Microorganisms in Clinical Genitourinary Samples.
Microorganisms
March 2023
Laboratory of Microbiology, Virgen de las Nieves University Hospital, Granada Institute of Biohealth Research (Ibs.), Avda. de las Fuerzas Armadas 2, 18014 Granada, Spain.
Microorganisms responsible for genitourinary infections increasingly include species other than conventional etiological agents that are of clinical and pathogenic relevance and therapeutic interest. This cross-sectional descriptive study selected samples from clinical genitourinary episodes between January 2016 and December 2019 in which emerging microbiological agents were detected. The patients' epidemiological characteristics, clinical presentation, antibiotic treatment, and outcome were studied to identify their pathogenic role.
View Article and Find Full Text PDF[Asymptomatic bacteriuria in pregnant women the normal condition of healthy women urine].
Urologiia
December 2022
Department of Urology, Rostov-on-Don, Russia.
Objective: to study the dynamics of the microbiota of a freshly excreted middle portion of urine in primigravida at different times of all three trimesters of pregnancy.
Materials And Methods: A single-center prospective observational cohort study was conducted with a consecutive enrollment of 30 women at different gestational ages: I - 8-12 weeks, II - 22-24 weeks, III - 30-32 weeks. A midstream specimen of morning vesical urine was taken for the study, then it was cultivated using nutrient media for aerobic and anaerobic microorganisms under appropriate conditions.
Is Bacteroides finegoldii a new bacterial pathogen?
Anaerobe
February 2023
Clinical Microbiology and Parasitology Service, Basurto University Hospital, 18 Avenida Montevideo, 48013, Bilbao, Biscay, Spain; Biocruces Bizkaia Health Research Institute, Cruces Plaza, 48903, Biscay, Spain. Electronic address:
Article Synopsis
- * The identification of B. finegoldii was done using MALDI-TOF MS and later confirmed by 16S rRNA sequencing.
- * This case report marks the first documented instance of B. finegoldii causing an infection in a human, linked to the presence of a neoplastic mass and potential fistula between the colon and bladder.
Chicken IgY reduces the risk of urinary tract infections in a murine model.
Front Microbiol
September 2022
Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, København, Denmark.
Introduction: Urinary tract infections (UTIs) with are a severe problem in disposed patients in modern healthcare. establishes recalcitrant biofilm infections and can develop antibiotic resistance. Gargling with avian egg yolk anti- antibodies (IgY) has shown clinical effect in preventing onset of chronic lung infections in patients with cystic fibrosis (CF).
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