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Peripheral precocious puberty secondary to severe hypothyroidism.
Arch Argent Pediatr
November 2024
Endocrinology Research Center Dr. César Bergadá, National Scientific Research Council and Techniques - FEI, Endocrinology Division; Hospital de General de Niños Ricardo Gutiérrez, City of Buenos Aires, Argentina.
Van Wyk-Grumbach syndrome is a rare form of severe hypothyroidism. We present a 10.9-year-old girl who consulted for genital bleeding, Tanner stage 2, and clinical manifestations of hypothyroidism.
View Article and Find Full Text PDFVan Wyk-Grumbach Syndrome and Gonadectomy.
Children (Basel)
July 2024
Instituto Mexicano del Seguro Social, UMAE Hospital General La Raza, Mexico City 02990, Mexico.
Van Wyk-Grumbach syndrome (VWGS) refers to the development of peripheral precocious puberty, long-standing hypothyroidism, and gonadal masses; when not diagnosed, an unnecessary gonadectomy may be performed. Herein, we present a case of a 10-year-old girl with Down's syndrome, short stature, and vitiligo who presented to our hospital with vaginal bleeding and a palpable pelvic mass. Upon ultrasound and topographical examination, bilateral ovarian masses with negative tumor markers were detected.
View Article and Find Full Text PDF[A case of Van Wyk-Grumbach syndrome with inherited RET gene variation].
Zhonghua Er Ke Za Zhi
August 2024
Department of Traditional Chinese Medicine, Children's Hospital of Fudan University, Shanghai 201102, China.
Severe Acquired Hypothyroidism and Van Wyk-Grumbach Syndrome in Two Children.
Case Rep Pediatr
July 2024
Department of Pediatrics Centre Hospitalier Universitaire Saint-Etienne, Avenue Albert Raimond, Saint-Priest en Jarez 42270, France.
Article Synopsis
- Chronic hypothyroidism in children can lead to growth issues, delayed skeletal maturity, and delayed puberty, as seen in the Van Wyk-Grumbach syndrome (VWGS), first reported in 1960.* -
- VWGS presents with symptoms like early breast development, galactorrhea, delayed bone age, and pituitary enlargement, and many cases share similar clinical and biochemical features, such as elevated TSH and low thyroxine levels.* -
- Treatment with thyroid hormone replacement has been effective in reversing the symptoms of VWGS, resulting in normal growth and thyroid function within six months for the patients studied.*
Solving the Dilemma: Van Wyk-Grumbach Syndrome.
Cureus
May 2024
Department of Pediatrics, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
The Van Wyk-Grumbach syndrome (VWGS) (hypothyroidism, ovarian mass, and precocious puberty) has been extensively documented in the literature as long-term hypothyroidism manifesting as an ovarian mass. The authors of this study describe this entity in a young girl, aged 10, who presented with abdominal pain with a multiloculated ovarian cyst. She was evaluated, and it was discovered that she had delayed bone age, precocious puberty, and a small height.
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