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A Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized Double-Blind Clinical Trial.
Drug Des Devel Ther
December 2024
Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China.
Article Synopsis
- The study investigates the effectiveness of esketamine as an adjunct to propofol sedation compared to sufentanil during minimally invasive rotary resection (MIRR) for breast tumors.
- Results show that patients receiving esketamine-propofol experienced significantly lower hypoxia rates (17.5%) and fewer airway interventions compared to those on sufentanil-propofol (39%).
- Overall, esketamine improves safety without affecting awakening time or patient satisfaction, making it a promising option for anesthesia during breast MIRR.
Factors Associated with Hypersensitivity, Management, and Treatment Options for Teeth with Molar Incisor Hypomineralisation.
Monogr Oral Sci
September 2024
Department of Dentistry, Faculty of Health Science, University of Brasília, Brasília, Brazil.
Tooth hypersensitivity is a common symptom in molar incisor hypomineralisation (MIH) patients and can affect children's quality of life. During daily routine, children with MIH often report sensitivity to various thermal and mechanical stimuli, and difficulty in achieving effective analgesia is a common issue becoming a challenge for dentists. Research has focused on the possible pathophysiological mechanisms behind this phenomenon, which, in turn, have not been determined.
View Article and Find Full Text PDFBrachial Plexus Injury Influences Efferent Transmission on More than Just the Symptomatic Side, as Verified with Clinical Neurophysiology Methods Using Magnetic and Electrical Stimulation.
Biomedicines
June 2024
Department Pathophysiology of Locomotor Organs, Poznań University of Medical Sciences, 28 Czerwca 1956 Str. No 135/147, 61-545 Poznań, Poland.
The variety of sources of brachial plexus injuries (BPIs) and the severity and similarity of their clinical symptoms with those of other injuries make their differential diagnosis difficult. Enriching their diagnosis with objective high-sensitivity diagnostics such as clinical neurophysiology may lead to satisfactory treatment results, and magnetic stimulation (MEP) might be an advantageous addition to the diagnostic standard of electrical stimulation used in electroneurography (ENG). The asymptomatic side in BPI cases sometimes shows only subclinical neurological deficits; this study aimed to clarify the validity and utility of using MEP vs.
View Article and Find Full Text PDFAntimicrobial therapies for chronic pain (part 2): the prevention and treatment of chronic pain.
Korean J Pain
July 2023
Department of Anesthesiology and Critical Care Medicine, Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
The discovery and development of antimicrobial therapies represents one of the most significant advancements in modern medicine. Although the primary therapeutic intent of antimicrobials is to eliminate their target pathogens, several antimicrobials have been shown to provide analgesia as a secondary benefit. Antimicrobials have demonstrated analgesic effects in conditions that involve dysbiosis or potential subclinical infection (, chronic low back pain with Modic type 1 changes; chronic prostatitis/chronic pelvic pain; irritable bowel syndrome; inflammatory bowel disease; functional gastrointestinal disorders/dyspepsia; myalgic encephalomyelitis/chronic fatigue syndrome), and might even prevent the chronification of pain after acute infections that are associated with excessive systemic inflammation (, post COVID-19 condition/long Covid, rheumatic fever).
View Article and Find Full Text PDFClinical thresholds in pain-related facial activity linked to differences in cortical network activation in neonates.
Pain
May 2023
Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
In neonates, a noxious stimulus elicits pain-related facial expression changes and distinct brain activity as measured by electroencephalography, but past research has revealed an inconsistent relationship between these responses. Facial activity is the most commonly used index of neonatal pain in clinical settings, with clinical thresholds determining if analgesia should be provided; however, we do not know if these thresholds are associated with differences in how the neonatal brain processes a noxious stimulus. The objective of this study was to examine whether subclinical vs clinically significant levels of pain-related facial activity are related to differences in the pattern of nociceptive brain activity in preterm and term neonates.
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