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18F-Sodium Fluoride PET/CT as a Tool to Assess Enthesopathies in X-Linked Hypophosphatemia.
Calcif Tissue Int
January 2025
Endocrinology Department, School of Medicine, Pontificia Universidad Católica de Chile, Av. Diagonal Paraguay 262, Cuarto Piso, Santiago, Chile.
X-linked hypophosphatemia (XLH) is a rare metabolic disorder characterized by elevated FGF23 and chronic hypophosphatemia, leading to impaired skeletal mineralization and enthesopathies that are associated with pain, stiffness, and diminished quality of life. The natural history of enthesopathies in XLH remains poorly defined, partly due to absence of a sensitive quantitative tool for assessment and monitoring. This study investigates the utility of 18F-NaF PET/CT scans in characterizing enthesopathies in XLH subjects.
View Article and Find Full Text PDFSubcutaneous injections of dextrose in musculoskeletal pain, a potential therapeutic intervention: scoping review.
Pain Manag
December 2024
Sports Medicine, Anahuac Mayab University, Mérida, Yucatan, Mexico.
Background: The aims of this review were to identify and to analyze the clinical studies that used subcutaneous injections of dextrose for treating musculoskeletal pain, in order to establish an overview.
Methods: A systematic search was carried out in scientific databases including Web of Science, Cochrane Central Register of Controlled Trials, PUBMED and other sources, up until March 2024. We included clinical studies that used subcutaneous injections of dextrose in the treatment of individuals with musculoskeletal pain associated with tendinopathies, enthesopathy, osteoarthritis, ligament sprains, muscle strains or bursitis of various locations.
Conventional radiography and correlated factors of enthesopathies of the Achilles tendon and plantar fascia in patients with axial spondyloarthritis.
Reumatismo
October 2024
Department of Biostatistics and Medical Informatics, Bezmialem Vakıf University, İstanbul.
Objective: This study aimed to investigate the correlated risk factors and presence of radiological enthesopathies of the Achilles tendon and plantar fascia in patients with axial spondyloarthropathy (axSpA).
Methods: 242 patients (121 female and 121 male) with axSpA were included in this study. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP), the Bath Ankylosing Spondylitis Radiology Index (BASRI), the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), and CRP were evaluated in all patients.
Arthralgia with risk of progression to psoriatic arthritis: role of clinical assessments and ultrasound as prognostic factors.
Rheumatology (Oxford)
October 2024
Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany.
Article Synopsis
- The study investigates delays in referring patients with psoriasis from dermatology to rheumatology, focusing on those with arthralgia (joint pain) who may be at risk for developing psoriatic arthritis (PsA).
- Out of 1,419 patients evaluated, 8.4% were classified as at-risk for PsA, with 29% progressing to the disease within one year.
- Key predictive factors for this progression included a family history of psoriasis, joint pain severity, duration of psoriasis, and specific ultrasound findings.
The role of GDF5 in regulating enthesopathy development in the Hyp mouse model of XLH.
J Bone Miner Res
August 2024
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, United States.
Article Synopsis
- X-linked hypophosphatemia (XLH) results from mutations in the PHEX gene, leading to bone issues like rickets and enthesopathy in adults, which causes pain and movement difficulties.
- In mice models of XLH, increased bone morphogenetic protein (BMP) and Indian hedgehog (IHH) signaling were found to play a significant role in the development of enthesopathy; blocking BMP signaling with palovarotene showed a reduction in these signals.
- The study also highlights that while growth/differentiation factor 5 (GDF5) isn't crucial for BMP/IHH signaling in normal entheses, its inappropriate activity in XLH contributes to enthesopathy, suggesting that targeting G
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