Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis refractory to both glucocorticosteroids and infliximab with a resultant pneumatosis and perforation requiring subtotal colectomy and end ileostomy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818971PMC
http://dx.doi.org/10.1155/2018/2431503DOI Listing

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