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Mitochondrial phenotype during torpor: Modulation of mitochondrial electron transport system in the Chilean mouse-opossum Thylamys elegans. | LitMetric

Mitochondrial phenotype during torpor: Modulation of mitochondrial electron transport system in the Chilean mouse-opossum Thylamys elegans.

Comp Biochem Physiol A Mol Integr Physiol

Département de Biologie, Laboratoire de Physiologie Animale Intégrative, Université du Québec, Rimouski G5L 3A1, QC, Canada.

Published: July 2018

AI Article Synopsis

  • - Mammalian torpor is a state where metabolic rate and body temperature decrease, and it can be quickly reversed, allowing animals to return to normal levels when they awaken.
  • - The study focused on key enzymes in the mitochondria of the Chilean mouse-opossum and found increased activity of certain complexes (I and IV) in the brain, heart, and liver during torpor, suggesting these organs are still active even when in a low metabolic state.
  • - Complex III showed higher activity in the kidneys and lungs during torpor, indicating its role in maintaining metabolism in these organs, while skeletal muscle displayed no significant changes, meaning it does not adapt much during torpor.

Article Abstract

Mammalian torpor is a phenotype characterized by a controlled decline of metabolic rate, generally followed by a reduction in body temperature. During arousal from torpor, both metabolic rate and body temperature rapidly returns to resting levels. Metabolic rate reduction experienced by torpid animals is triggered by active suppression of mitochondrial respiration, which is rapidly reversed during rewarming process. In this study, we analyzed the changes in the maximal activity of key enzymes related to electron transport system (complexes I, III and IV) in six tissues of torpid, arousing and euthermic Chilean mouse-opossums (Thylamys elegans). We observed higher maximal activities of complexes I and IV during torpor in brain, heart and liver, the most metabolically active organs in mammals. On the contrary, higher enzymatic activities of complexes III were observed during torpor in kidneys and lungs. Moreover, skeletal muscle was the only tissue without significant differences among stages in all complexes evaluated, suggesting no modulation of oxidative capacities of electron transport system components in this thermogenic tissue. In overall, our data suggest that complexes I and IV activity plays a major role in initiation and maintenance of metabolic suppression during torpor in Chilean mouse-opossum, whereas improvement of oxidative capacities in complex III might be critical to sustain metabolic machinery in organs that remains metabolically active during torpor.

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Source
http://dx.doi.org/10.1016/j.cbpa.2017.12.014DOI Listing

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