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Effect of fezolinetant on patient-reported quality-of-life outcomes: Data from a phase 3b study (DAYLIGHT) of the treatment of moderate to severe vasomotor symptoms associated with menopause in women considered unsuitable for hormone therapy.
Maturitas
November 2024
Hormone Hamburg, Hamburg, Germany. Electronic address:
Objective: To report patient-reported quality-of-life (QOL) outcomes in the DAYLIGHT study.
Study Design: DAYLIGHT was a phase 3b, randomized, double-blind, 24-week, placebo-controlled study. Participants were women aged ≥40 to ≤65 years with moderate to severe vasomotor symptoms (VMS) considered unsuitable for hormone therapy (HT) (contraindications, caution, stoppers, or averse) randomized 1:1 to placebo or fezolinetant 45 mg once daily.
Enhanced detection of measurement anomalies in cartridge cases using 3D gray-level co-occurrence matrix.
Forensic Sci Int
January 2025
Department of Forensic Science and Technology, Sichuan Police College, No. 186, Longtouguan Road, Jiangyang District, Luzhou 646000, China; Sichuan Provincial Key Lab of Intelligent Policing, No. 186, Longtouguan Road, Jiangyang District, Luzhou 646000, China. Electronic address:
The firing pin impression left on the base of a cartridge case is a critical analytical feature in forensic science. To address the limitations of traditional manual trace analysis and mitigate the risk of secondary damage to physical evidence, we employ a line laser displacement sensor to capture and analyze three-dimensional (3D) traces of fired cartridge cases. However, when using laser displacement sensors to collect traces from metal cartridge cases, the high curvature and reflectivity of the metal surface can cause specular reflections, potentially leading to measurement anomalies in the firing pin impressions.
View Article and Find Full Text PDFAn Evaluation of Iloperidone for Mania in Bipolar I Disorder.
Ann Pharmacother
January 2025
Division of Pharmacy Practice and Administration, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.
Objective: To review the efficacy of iloperidone for mania associated with bipolar I disorder and discuss its safety profile (eg, QTc prolongation, orthostatic hypotension, and metabolic adverse effects).
Data Sources: Literature was identified using PubMed (1966-September 2024), OVID (1984-November 2024), and clinicaltrials.gov.
State-Level Helmet Use Laws, Helmet Use, and Head Injuries in EMS Patients Involved in Motorcycle Collisions.
Prehosp Emerg Care
January 2025
Clinical and Research Services, ImageTrend Inc.
Objectives: Motorcycle helmets save lives and reduce serious injury after motorcycle collisions (MCC). In 2022, 18 states had laws requiring helmet use by motorcyclists aged ≥21 years. Our objective was to compare helmet use and head trauma in emergency medical services (EMS) patients involved in MCC in states with and without helmet use laws.
View Article and Find Full Text PDFFingerprint Sweat Pore Density in Patients with Oligodontia: A Controlled Clinical Trial.
Biomedicines
December 2024
Department of Orthodontics, University of Münster, 48149 Münster, Germany.
There is a lack of evidence for the relationship between sweat pores and tooth agenesis. The aim of this study was to compare sweat pore density on fingertips between a group of patients with oligodontia and a control group without tooth agenesis. This parallel-group controlled clinical trial included 28 patients.
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