AI Article Synopsis
- The trillions of microbes in the human body influence health and disease through various genetic, environmental, and lifestyle factors, shaping the human ecosystem.
- Researchers are exploring ways to design microbes as therapeutic agents, which could enhance drug delivery and restore balance in disrupted microbial communities.
- Lactic acid bacteria (LAB) have a safe history of use in food and health, making them suitable for engineered applications, and the review discusses genetic tools and future possibilities for LAB-based therapeutic systems.
Article Abstract
The trillions of microbes hosted by humans can dictate health or illness depending on a multitude of genetic, environmental, and lifestyle factors that help define the human ecosystem. As the human microbiota is characterized, so can the interconnectivity of microbe-host-disease be realized and manipulated. Designing microbes as therapeutic agents can not only enable targeted drug delivery but also restore homeostasis within a perturbed microbial community. Used for centuries in fermentation and preservation of food, lactic acid bacteria (LAB) have a long history of safe, and occasionally health promoting, interactions with the human gut, making them ideal candidates for engineered functionality. This review outlines available genetic tools, recent developments in biomedical applications, as well as potential future applications of synthetic biology to program LAB-based therapeutic systems.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139064 | PMC |
| http://dx.doi.org/10.1016/j.copbio.2018.01.028 | DOI Listing |
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