Positron emission tomography (PET) computed tomography (CT) with 2-[fluorine-18] fluoro-2-deoxy-d-glucose (FDG) has been established as an effective modality for evaluation of cancer. Interpretations of patterns of physiologic F-FDG uptake by the heart is particularly difficult given the wide normal variations of F-FDG metabolic activity observed. Atypical patterns of focal or diffuse physiologic cardiac F-FDG uptake and post-therapeutic effects after radiation therapy, systemic diseases, or cardiomyopathy may also be confused with malignant disease on F-FDG PET/CT. In this article, we review the variations of normal cardiac F-FDG uptake observed in oncology patients and the appearances of other patterns of pathologic metabolic activity, related or not related to the malignancy being investigated, that may lead to false-negative and false-positive results.

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http://dx.doi.org/10.1067/j.cpradiol.2018.02.002DOI Listing

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