A prospective study was performed to determine the value of magnetic resonance imaging (MRI) in the detection of retroperitoneal lymphadenopathy. Fifty patients with known malignancy, who demonstrated enlarged lymph nodes on computed tomography (CT), were entered into the study. The best visualization of retroperitoneal lymphadenopathy was found with a multislice spin-echo pulse sequence having a repetition time of 2000 msec, and echo delay of 30 msec. Nodes had a signal intensity lower than fat and greater than muscle with this pulse sequence. More than 90% of the lymphadenopathies as shown by CT could be demonstrated by MRI. Due to the flow-void phenomenon, blood vessels did not have any signal and were easily visualized without the use of intravenous contrast medium. Sagittal and coronal images added to an appreciation of the size of nodes and the extent of retroperitoneal lymphadenopathy. Ten normal volunteers were also imaged by MRI and their retroperitoneal nodes were well demonstrated.
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