AI Article Synopsis
- Germinal centers (GCs) are crucial for B cell affinity maturation, but the regulation of their cellular output is not fully understood.
- Researchers identify that plasmablasts, which are important for antibody production, emerge at the interface of the GC and T zone (GTI) early in the GC response.
- Two key factors influencing this emergence are Tfh-derived IL-21, which promotes plasmablast production, and TNFSF13 (APRIL) from specific fibroblastic reticular cells, with blocking their receptor reducing plasmablast numbers, suggesting a role in immune responses.
Article Abstract
Germinal centers (GCs) are the sites where B cells undergo affinity maturation. The regulation of cellular output from the GC is not well understood. Here, we show that from the earliest stages of the GC response, plasmablasts emerge at the GC-T zone interface (GTI). We define two main factors that regulate this process: Tfh-derived IL-21, which supports production of plasmablasts from the GC, and TNFSF13 (APRIL), which is produced by a population of podoplanin CD157 fibroblastic reticular cells located in the GTI that are also rich in message for IL-6 and chemokines CXCL12, CCL19, and CCL21. Plasmablasts in the GTI express the APRIL receptor TNFRSF13B (TACI), and blocking TACI interactions specifically reduces the numbers of plasmablasts appearing in the GTI. Plasma cells generated in the GTI may provide an early source of affinity-matured antibodies that may neutralize pathogens or provide feedback regulating GC B cell selection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881458 | PMC |
| http://dx.doi.org/10.1084/jem.20160832 | DOI Listing |
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