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VPS28 regulates triglyceride synthesis via ubiquitination in bovine mammary epithelial cells.
Sci Rep
December 2024
College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China.
VPS28 (vacuolar protein sorting 28) is a subunit of the endosomal sorting complexes required for transport (ESCRTs) and is involved in ubiquitination. Ubiquitination is a critical system for protein degradation in eukaryotes. Considering the recent findings on the role of ubiquitination in the regulation of lipid metabolism, we hypothesized that VPS28 might affect the expression of genes involved in milk fat synthesis.
View Article and Find Full Text PDFMechanism to disrupt ESCRT-mediated intracellular trafficking through Vps28-small molecules interaction: an in silico approach.
J Biomol Struct Dyn
December 2024
Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana, India.
The ESCRT (Endosomal Sorting Complex Required for Transport) machinery comprising protein complexes ESCRT-0 to ESCRT-III and Vps4 plays a pivotal role in intracellular trafficking, a process of endocytosing cell surface proteins into the cell for various biological activities. The ESCRT protein complexes are sequentially assembled which interact amongst each other to form a functional ESCRT machinery. Deregulation of these events are shown to be involved in various disease development including tumor formation and viral infections.
View Article and Find Full Text PDFNFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency.
Cell Mol Life Sci
November 2024
Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Endosomal Sorting Complexes Required for Transport (ESCRTs) are crucial for delivering membrane receptors or intracellular organelles for lysosomal degradation which provides the cell with lysosome-derived nutrients. Yet, how ESCRT dysfunction affects cell metabolism remained elusive. To address this, we analyzed transcriptomes of cells lacking TSG101 or VPS28 proteins, components of ESCRT-I subcomplex.
View Article and Find Full Text PDFDiversity, Origin and Evolution of the ESCRT Systems.
bioRxiv
February 2024
National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA.
Endosomal Sorting Complexes Required for Transport (ESCRT) play key roles in protein sorting between membrane-bounded compartments of eukaryotic cells. Homologs of many ESCRT components are identifiable in various groups of archaea, especially in Asgardarchaeota, the archaeal phylum that is currently considered to include the closest relatives of eukaryotes, but not in bacteria. We performed a comprehensive search for ESCRT protein homologs in archaea and reconstructed ESCRT evolution using the phylogenetic tree of Vps4 ATPase (ESCRT IV) as a scaffold, using sensitive protein sequence analysis and comparison of structural models to identify previously unknown ESCRT proteins.
View Article and Find Full Text PDFThe Endosomal Sorting Complex, ESCRT, has diverse roles in blood progenitor maintenance, lineage choice and immune response.
Biol Open
June 2024
Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
Article Synopsis
- * In Drosophila, researchers found that only certain ESCRT components (Vps28 and Vp36) are essential for the development of blood cells in the larval lymph gland.
- * The study reveals that ESCRTs play important roles in both supporting progenitor cells and regulating differentiation, highlighting their influence on cell fate and adaptability in changing environments.
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