AI Article Synopsis
- Nuclear receptors (NRs) are promising targets for treating diseases linked to metabolic syndrome.
- Natural products have evolved to interact effectively with biological targets, making them a valuable source of potential ligands for NRs.
- The review focuses on the liver X (LXR) and farnesoid X receptors (FXR), their interaction with retinoid X receptors (RXR), and explores their potential in precision medicine.
Article Abstract
Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting pool of potential ligands since they have been refined under evolutionary pressure to interact with proteins or other biological targets. This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed.
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| http://dx.doi.org/10.1016/j.biotechadv.2018.03.003 | DOI Listing |
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