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Article Synopsis
  • Pfeiffer syndrome (PS) is a rare genetic disorder affecting facial and limb bones, with the most severe forms being types 2 and 3.
  • In this case, a 10-year-old boy with PS type 2 needed dental surgery under general anesthesia, and special care was taken due to his Chiari malformation to avoid neck hyperextension.
  • The anesthesia team used a combination of sevoflurane and nitrous oxide for induction and opted for oral intubation instead of nasotracheal intubation, successfully managing the procedure with no complications.
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Objective: To show the effectiveness and safety of topical sevoflurane after ambulatory and prolonged administration in patients with refractory vascular ulcers .

Methods: Retrospective observational study analysing clinical improvement and vascular ulcers surface area variation after topical application of sevoflurane. Inclusion criteria were patients with painful vascular ulcers refractory to usual therapies and who were treated with topical sevoflurane for at least 36 months.

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The combination of postmortem sevoflurane ventilation and in situ topical cooling provides improved 6 hours lung preservation in an uncontrolled DCD porcine model.

J Heart Lung Transplant

October 2024

Latner Thoracic Research Laboratories, Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Recent clinical series on donation after uncontrolled cardiovascular death (uDCD) reported successful transplantation of lungs preserved by pulmonary inflation up to 3 hours postmortem. This study aims to investigate the additive effects of in situ lowering of intrathoracic temperature and sevoflurane preconditioning on lung grafts in a porcine uDCD model.

Methods: After uDCD induction, donor pigs were allocated to one of the following groups: control-static lung inflation only (SLI); TC - SLI + continuous intrapleural topical cooling (TC); or TC+Sevo - SLI + TC + sevoflurane.

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Article Synopsis
  • This study investigates the effectiveness of adding Ketorolac to traditional pupil-dilating medications in children undergoing procedures for retinoblastoma under anesthesia.
  • Results showed that using the new four-drug combination reduced the average anesthesia time from 25 minutes to 16 minutes, representing a 36% decrease.
  • The findings suggest that the new combination not only reduces anesthesia duration for children but also decreases the overall exposure to anesthetic gases for medical staff and minimizes the trauma associated with multiple eye drops.
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Seeing is Believing: Chasing Sevoflurane Vapor Trails.

J Perianesth Nurs

April 2024

Anesthesia Department, Te Whatu Ora Health New Zealand Waikato, Waikato Hospital, Hamilton, New Zealand. Electronic address:

Purpose: Sevoflurane is an inhalational general anesthetic that has been used recently to treat chronic, painful lesions, reportedly supporting analgesia and wound healing. The potential for repeated exposure to off-gassed sevoflurane vapor, especially outside the air-conditioned operating theatre environment, is of some concern.

Design: This paper explores the qualitative and quantitative pathing of off-gassed sevoflurane from a topically applied liquid source.

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