The unregulated use of organophosphates (OPs) as pesticides and toxic chemical warfare agents demands their continuous monitoring from a human health perspective. This study describes a fluorescence turn-on sensing assay for the selective quantification of OPs in aqueous medium. Metal complexes of two different Biginelli derivatives were processed in water through a reprecipitation technique. The engineered self-assembly of the pyridyl-2-cobalt complex (L1·Co(II)) was employed to selectively detect malathion while the pyridyl-4-cobalt complex (L2·Co(II)) could estimate azamethiphos fluorimetrically up to a detection limit of 9.2 nM and 11 nM, respectively. Furthermore, the pesticide degradation ability of OPs was assessed using a 31P-NMR technique. This new paradigm expands the versatility of Biginelli derivatives as promising sensing platforms via metal complexation which may further be explored for estimation of analytes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/C8DT00150B | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design of an efficient magnetic brush solid acid and its catalytic use in organic reactions.
Sci Rep
January 2025
Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, 616, Birkat Al Mauz, Nizwa, Sultanate of Oman.
In this research, with the Green Chemistry approach, to load more sulfonic acid active sites on catalyst surfaces, a nanocomposite material based on core-shell magnetite coated with vinyl silane and a sulfonated polymeric brush-like structure is designed and synthesized as a new class of efficient solid acid catalysts, referred to as FeO@VS-APS brush solid acid. The synthesized catalyst was comprehensively characterized by a range of instrumental techniques, including XRD, SEM, TEM, FT-IR, EDX, TGA, and VSM. The activity of the catalyst was evaluated in Biginelli, Strecker, and esterification reactions.
View Article and Find Full Text PDFUnveiling the potential anticancer activity of new dihydropyrimidines through dual inhibition of EGFR and TrkA: Design, synthesis, and in silico study.
Bioorg Chem
January 2025
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Article Synopsis
- - A series of dihydropyrimidine compounds were created as inhibitors of tyrosine kinases through a one-pot Biginelli reaction, yielding a variety of 1,4-DHPM hybrids by alkylating with different chloroacetylamine derivatives.
- - These synthesized compounds were tested for their ability to inhibit cancer cell growth in different cell lines (HCT-116, PC-3, MCF-7) and showed that compounds 8h and 8i were the most effective, with low concentrations needed to inhibit cancer cells while being more selective towards normal cells.
- - Further analysis revealed that compound 8h was particularly potent in inhibiting key kinases (EGFR and Trk
Synthesis, characterization, and evaluation of pyrimidinone-linked thiazoles: DFT analysis, molecular docking, corrosion inhibition, and bioactivity studies.
Heliyon
October 2024
Jai Research Foundation, Valvada, Vapi, Gujarat, 396105, India.
The paper describes the construction of a new series of pyrimidinone-linked thiazole derivatives through bromination of the initial Biginelli reaction product followed by the Hantzsch thiazole synthesis route. Various analytical techniques, including FT-IR, H NMR, C NMR, and LCMS analysis, were employed to confirm the formation of the products. The synthesized compounds were primarily evaluated for their antibacterial activity, with a specific focus on their IC values.
View Article and Find Full Text PDFChlorine containing tetrahydropyrimidines: Synthesis, characterization, anticancer activity and mechanism of action.
Bioorg Chem
December 2024
Department of Science, Institute for Information Technologies Kragujevac, University of Kragujevac, Kragujevac 34000, Serbia. Electronic address:
The aim of the presented research was to explore anticancer potential of eleven newly synthesized tetrahydropyrimidine derivatives. The compounds were synthesized via Biginelli multicomponent one-pot reaction using different derivatives of vanillin, ethyl 4-chloroacetoacetate and (N-methyl)urea. The cytotoxic effects of the compounds were examined on three human malignant cell lines (HeLa, K562, and MCF7), and normal lung fibroblasts MRC-5.
View Article and Find Full Text PDFThis study focuses on the designing and characterization, and anticancer evaluation of chitosan-based nanoparticles (NPs) loaded (enriched) with a Biginelli hybrid compound (BH). NPs based on chitosan (CH) or chitosan oligosaccharide lactate (CHOL), are carefully designed to encapsulate a tetrahydropyrimidine derivative (BH) with already proven anticancer properties. The formulations were evaluated for their physicochemical properties, including particle size distribution and morphology, using techniques such as infrared spectroscopy, scanning electron microscopy, and X-ray diffraction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!