Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1183/13993003.02559-2017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dasatinib-Induced Pulmonary Arterial Hypertension in Chronic Myeloid Leukaemia: A Case Report and Literature Review.
Respirol Case Rep
March 2025
Pulmonary Hypertension Clinic, Division of Cardiology and Advanced Heart Failure Community Health Network Indianapolis Indiana USA.
Dasatinib, a second-generation tyrosine kinase inhibitor used for treating chronic myeloid leukaemia (CML), is associated with rare but significant adverse effects, including pulmonary arterial hypertension. This condition is thought to result from endothelial dysfunction and vascular remodelling linked to Src kinase inhibition. Symptoms such as progressive dyspnoea and fatigue may appear months or years after starting therapy, emphasising the need for long-term vigilance.
View Article and Find Full Text PDFCIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability.
Commun Biol
March 2025
National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Acute pancreatitis can lead to systemic inflammation and multiple organ damage. Increased endothelial permeability is a hallmark of systemic inflammation. Several studies have demonstrated that cold-inducible RNA-binding protein (CIRP) functions as a proinflammatory factor in various diseases.
View Article and Find Full Text PDFHemodynamic phenotypes in congenital diaphragmatic hernia and their association with morbidity and mortality.
Bol Med Hosp Infant Mex
March 2025
Clinical Research Service, Hospital Infantil de México Federico Gómez, Mexico City. Mexico.
Background: Congenital diaphragmatic hernia (CDH) is a severe condition associated with high morbidity and mortality. Its severity correlates with the degree of pulmonary hypoplasia. Recent literature has emphasized the importance of identifying distinct hemodynamic phenotypes (HP) to guide physiology-based management.
View Article and Find Full Text PDFCPHNet: a novel pipeline for anti-HAPE drug screening via deep learning-based Cell Painting scoring.
Respir Res
March 2025
Department of Pharmacy, Medical College of Qinghai University, Xining, Qinghai, 810001, China.
Background: High altitude pulmonary edema (HAPE) poses a significant medical challenge to individuals ascending rapidly to high altitudes. Hypoxia-induced cellular morphological changes in the alveolar-capillary barrier such as mitochondrial structural alterations and cytoskeletal reorganization, play a crucial role in the pathogenesis of HAPE. These morphological changes are critical in understanding the cellular response to hypoxia and represent potential therapeutic targets.
View Article and Find Full Text PDFSchistosomiasis is the second most dangerous parasitic disease, affecting approximately 200 million people worldwide. Chronic Schistosomiasis, especially the hepatosplenic form, can lead to the development of pulmonary arterial hypertension and has been classified as a distinct entity referred to as "Schistosomiasis-associated pulmonary arterial hypertension" (Sch-PAH). Several mechanisms may play a role in the pathogenesis of Sch-PAH, which include peri-ovular granulomatous inflammation with subsequent vascular remodeling.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!