Objective: RAId is a software package that has been actively developed for the past 10 years for computationally and visually analyzing MS/MS data. Founded on rigorous statistical methods, RAId's core program computes accurate E-values for peptides and proteins identified during database searches. Making this robust tool readily accessible for the proteomics community by developing a graphical user interface (GUI) is our main goal here.
Results: We have constructed a graphical user interface to facilitate the use of RAId on users' local machines. Written in Java, RAId_GUI not only makes easy executions of RAId but also provides tools for data/spectra visualization, MS-product analysis, molecular isotopic distribution analysis, and graphing the retrieval versus the proportion of false discoveries. The results viewer displays and allows the users to download the analyses results. Both the knowledge-integrated organismal databases and the code package (containing source code, the graphical user interface, and a user manual) are available for download at https://www.ncbi.nlm.nih.gov/CBBresearch/Yu/downloads/raid.html .
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http://dx.doi.org/10.1186/s13104-018-3289-6 | DOI Listing |
Alzheimers Dement
December 2024
University of Manitoba, Winnipeg, MB, Canada.
Background: Mitochondrial bioenergetics are essential for cellular function, specifically the intricacies of the electron transport chain (ETC), with Complex IV playing a crucial role in unraveling the mechanisms governing energy production. Mathematical models offer a valuable approach to simulate these complex processes, providing insights into normal mitochondrial function and aberrations associated with various diseases, including neurodegenerative disorders. Our research focuses on introducing and refining a mathematical model, emphasizing Complex IV in the ETC, with objectives including incorporating mitochondrial activity modulation using inhibiting and uncoupling reagents, akin to oxygen consumption experiments.
View Article and Find Full Text PDFSci Rep
January 2025
Dr. D. Y. Patil Vidyapeeth, Pune, Dr. D. Y. Patil School of Science & Technology, Tathawade, Pune, India.
Smart wearable devices detection and recording of people's everyday activities is critical for health monitoring, helping persons with disabilities, and providing care for the elderly. Most of the research that is being conducted uses a machine learning-based methodology; however, these approaches frequently have issues with high computing resource consumption, burdensome training data gathering, and restricted scalability across many contexts. This research suggests a behaviour detection technology based on multi-source sensing and logical reasoning to address these problems.
View Article and Find Full Text PDFPhytopathology
January 2025
Agricultural University of Hebei, 289 Lingyusi, Baoding, Baoding, Hebei, China, 071001;
Wheat leaf rust, caused by Erikss. (), is one of the most devastating diseases in common wheat ( L.) globally.
View Article and Find Full Text PDFEnviron Mol Mutagen
December 2024
Research and Development, Preclinical Safety, Sanofi, Industriepark Hoechst, Frankfurt am Main, Germany.
Genotoxicity is a critical determinant for assessing the safety of pharmaceutical drugs, their metabolites, and impurities. Among genotoxicity tests, mechanistic assays such as the MultiFlow® DNA damage assay (MFA) allows the investigations on mode of action (MoA) of DNA damage through four mechanistic markers recorded at two time points. Previous studies have shown that machine learning (ML) can enhance precision on classifying the MoA of genotoxicants.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Recent advances in computer-aided design tools have helped rapidly advance the development of wireframe DNA origami nanostructures. Specifically, automated tools now exist that can convert an input polyhedral mesh into a DNA origami nanostructure, greatly reducing the design difficulty for wireframe DNA origami nanostructures. However, one limitation of these automated tools is that they require a designer to fully conceptualize their intended nanostructure, which may be limited by their own preconceptions.
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