Nickel-Catalyzed System for the Cross-Coupling of Alkenyl Methyl Ethers with Grignard Reagents under Mild Conditions.

Org Lett

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), UMR 8231 , ESPCI Paris/CNRS/PSL Research University, 10 rue Vauquelin , Paris 75231 Cedex 05 , France.

Published: April 2018

A nickel-catalyzed cross-coupling of alkenyl methyl ethers with Grignard reagents, under mild conditions, is described. These conditions allowed access to various stilbenes and heterocyclic stilbenic derivatives as well as to a potential anticancer agent DMU-212.

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http://dx.doi.org/10.1021/acs.orglett.8b00313DOI Listing

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