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Passionate Homicides and Overkilling. A Forensic Case Series of Overkill in Rome (Italy) from 1999 to 2015.
Clin Ter
November 2024
Department of Clinical and Experimental Medicine, Section of Legal Medicine, University of Foggia, Italy.
Background: In forensics, the term overkill refers to the modus operandi of the offender that goes beyond the immediate need to kill the victim, but not beyond the borders of cruelty. The killer - unable to stop his murderous impulse - seems to want to make sure the victim is dead, repeatedly hitting the corpse. From a forensic point of view, this type of murder is characterized by bloody crime scenes and the discovery of brutal wounds on the victim's body.
View Article and Find Full Text PDFA PSMA-targeted Tri-specific Killer Engager enhances NK cell cytotoxicity against prostate cancer.
Cancer Immunol Res
November 2024
University of Minnesota, Minneapolis, Minnesota, United States.
Natural killer (NK) cell tumor infiltration is associated with good prognosis in patients with metastatic castration-resistant prostate cancer (mCRPC). NK cells recognize and kill targets by a process called natural cytotoxicity. We hypothesized that promoting an antigen-specific synapse with co-activation may enhance NK cell function in mCRPC.
View Article and Find Full Text PDFA qualitative study to inform the development of a decision support tool for the diagnosis of pulmonary tuberculosis in Tigray, Ethiopia.
BMC Med Inform Decis Mak
November 2024
School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Background: Tuberculosis (TB) is Ethiopia's leading infectious killer disease. The war in the Tigray region of Ethiopia has resulted in the disruption of TB care services. Prediction models are recommended to aid the diagnosis of TB in resource-limited settings.
View Article and Find Full Text PDFValidation of LC-MS/MS method for opioid monitoring in Valencia City wastewater: Assessment of synthetic wastewater as potential aid.
Sci Total Environ
October 2024
Environmental and Food Safety Research Group of the University of Valencia (SAMA-UV), Research Center on Desertification (CIDE), CSIC-UV-GV, Moncada-Naquera Road km 4.5, 46113 Moncada, Valencia, Spain.
In this study, a comprehensive and sensitive method for the simultaneous detection of 17 opioids (OPs) and their human metabolites in wastewater using high-performance liquid chromatography coupled to tandem mass spectrometry was validated. The chromatographic separations of opioids were carried out on a Kinetex® Biphenyl column (1.7 μm, 100 Å, 50 × 2.
View Article and Find Full Text PDFUnderstanding treatment of pain during SARS-CoV-2 pandemic in a two-year intercity longitudinal study using wastewater-based epidemiology.
J Hazard Mater
June 2024
Department of Chemistry, University of Bath, Bath BA2 7AY, UK. Electronic address:
SARS-CoV-2 pandemic had a significant impact on the society, economy, and health of people around the world with consequences that need to be better understood for future pandemic preparedness. This manuscript provides insights into the usage of pharmaceuticals for pain treatment management throughout SARS-CoV-2 pandemic. Four towns and cities with a total population of > 1 million people covering an area of 2000 km in South West England were monitored for twenty-four months.
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