Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/nph.15091 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure.
Arch Toxicol
January 2025
Department of Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraβe 15, 04318, Leipzig, Germany.
Testing for developmental toxicity is an integral part of chemical regulations. The applied tests are laborious and costly and require a large number of vertebrate test animals. To reduce animal numbers and associated costs, the zebrafish embryo was proposed as an alternative model.
View Article and Find Full Text PDFNeuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.
JAMA Netw Open
December 2024
Department of Psychological and Brain Sciences, Washington University in St Louis, Missouri.
Importance: The extent to which neuroanatomical variability associated with early substance involvement, which is associated with subsequent risk for substance use disorder development, reflects preexisting risk and/or consequences of substance exposure remains poorly understood.
Objective: To examine neuroanatomical features associated with early substance use initiation and to what extent associations may reflect preexisting vulnerability.
Design, Setting, And Participants: Cohort study using data from baseline through 3-year follow-up assessments of the ongoing longitudinal Adolescent Brain Cognitive Development Study.
Background: African Americans are among the most vulnerable demographic groups to both sleep deficiencies and Alzheimer's disease (AD)3. ABCA7-80 (rs115550680) known as adenosine triphosphate (ATP)-binding cassette member 7, plays a role in the transport of amyloid precursor protein, clearance of cellular Aβ, and lipid metabolism: three processes associated with late-onset AD2. Slow oscillations, which characterize non-REM sleep, are implicated in waste clearance and memory consolidation in the brain1.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Child Health and Development Studies, Public Health Institute, Oakland, CA, USA.
Background: Environmental factors are increasingly being recognized as significant contributors to Alzheimer's and Related Dementias (ADRD). Previously, we reported that higher serum concentrations of DDE, the highly persistent metabolite of the pesticide DDT was associated with increased risk of Alzheimer's disease. We further demonstrated in cell and animal models that DDT and DDE increase amyloid pathology in the brain (Fig.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: Tau pathology is closely related to cognitive decline in Alzheimer's disease (AD). Neurodegeneration is the putative mechanism by which tau leads to cognitive deficits. However, there is limited work on the associations between tau, neurodegeneration, and specific cognitive domains.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!