We discuss here the differential diagnosis of carpal ankylosis along with the second and third metacarpals of the right hand in an adult male skeleton buried in a kurgan from Mayemer, Kazakhstan (86-242 AD, 95.4% cal.). Our assessment was conducted via macroscopic analysis as well as with the use of radiographic methods. Several groups of pathologies were considered: congenital diseases, inflammatory and infectious diseases, and trauma. Differential diagnosis was challenging due to the very poor preservation of the skeleton, and while several diseases are possible (e.g., rheumatoid arthritis, spondylarthropathy), we think the fusion is most likely of traumatic origin. Evidence for trauma was found, suggesting a scaphocapitate fracture syndrome, followed by ankylosis.
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http://dx.doi.org/10.1016/j.ijpp.2015.11.004 | DOI Listing |
Clin Exp Pediatr
December 2024
Laboratório de Soroepidemiologia, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Background: Diagnosing and predicting neonatal sepsis is challenging because of its nonspecific symptoms, lack of diagnostic criteria consensus, and absence of early, sensitive, and specific diagnostic laboratory tests.
Purpose: To evaluate the diagnostic and prognostic potential of adrenomedullin (ADM), interleukin-6 (IL-6), and C-reactive protein (CRP) in late-onset neonatal sepsis (LOS).
Methods: We studied 53 neonates with culture-proven LOS by sampling at admission and on antibiotic treatment days 3 and 7.
South Afr J Crit Care
July 2024
Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Background: Melioidosis cases are increasing in Southeast Asia, posing a significant challenge owing to the rising number of diabetic and immune compromised patients. Pneumonia is the most common presentation of melioidosis, while cutaneous melioidosis is rare.
Objectives: We report a case of primary cutaneous melioidosis (PCM) that eventually required intensive care unit (ICU) management.
Front Cell Infect Microbiol
December 2024
Department of Obstetrics, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.
Background: Existing literature indicates that Gestational diabetes mellitus (GDM) and maternal obesity disrupt the normal colonization of the neonatal gut microbiota alone. Still, the combined impact of GDM and excessive gestational weight gain (EGWG) on this process remains under explored. The association between gestational weight gain before/after GDM diagnosis and neonatal gut microbiota characteristics is also unclear.
View Article and Find Full Text PDFFront Surg
December 2024
Cantor Spine Center at the Paley Institute, West Palm Beach, FL, United States.
Bertolotti's Syndrome, a subset of lumbosacral transitional vertebrae (LSTV), is one cause of chronic low back pain (LBP), and a commonly overlooked differential diagnosis. The incidence of Bertolotti's Syndrome has been underestimated in the past and is common in those of younger ages around 30-40. Although diagnostics, imaging methods, and treatment algorithms have been improved in the past few years, there is no gold standard and more long-term, prospective research is needed.
View Article and Find Full Text PDFPeerJ
December 2024
The First School of Clinical Medicine, Lanzhou University, LanZhou, Gansu, China.
Background: It has been demonstrated that nintedanib can inhibit the proliferation of gastric cancer cells, but the specific mechanism of action is unclear.
Objective: Investigating the changes of key factors involved in gene transcription and post-transcriptional regulation during the process of treating gastric cancer with nintedanib.
Methods: In this study, we performed transcriptome sequencing on gastric cancer cell groups treated with nintedanib and control groups.
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