Fibrous entheses have been widely used to study activity-related stress to infer behavioural patterns in past populations. Unlike their fibrocartilaginous counterparts, the effect of disease processes has been less widely discussed in the osteoarchaeological literature. This study uses a literature review to ascertain whether specific pathological changes should be taken into account when recording fibrous entheses. Due to the anatomical structure of fibrous entheses it was hypothesised that diseases which affect the structure of bone or the periosteum might be a factor in causing entheseal changes. A search of over one hundred terms was performed in PubMed with no year range stipulated, but no papers were found which related to entheseal changes caused by any of the expected pathological processes. The paucity of literature might be due to lack of symptoms in living individuals, it is therefore suggested that a systematic study of skeletal remains is performed using recently developed recording methods to determine if pathological conditions need to be taken into account when recording entheseal changes to study activity-related stress. The search did highlight a link between calcific tendinitis and cortical erosion at fibrous entheses, and it is recommended that this is taken into account when interpreting entheseal changes in past populations.
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http://dx.doi.org/10.1016/j.ijpp.2013.03.007 | DOI Listing |
J Orthop Res
January 2025
Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Enthesitis, or inflammation specific to sites in the body where tendon inserts into bone, can arise in isolated joints from overuse or in multiple joints as a complication of an autoimmune condition such as psoriatic arthritis or spondyloarthritis. However, the pathogenesis of enthesitis is not well understood, so treatment strategies are limited. A clinically relevant animal model of enthesitis would allow investigators to determine mechanisms driving the disease and evaluate novel therapies.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Overuse injury is a frequent diagnosis in occupational medicine and athletics. Using an established model of upper extremity overuse, we sought to characterize changes occurring in the forepaws and forelimbs of mature female rats (14-18 months of age). Thirty-three rats underwent a 4-week shaping period, before performing a high-repetition low-force (HRLF) task for 12 weeks, with the results being compared to 32 mature controls.
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
Objectives: This pilot study aimed to identify early predictors of drug retention in patients with clinically active peripheral psoriatic arthritis who initiated or switched to therapy with biologic and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs).
Methods: Clinical and ultrasound assessments were conducted at baseline (t0) and subsequently at 1 (t1), 3 (t3), and 6 (t6) months. Ultrasound evaluations targeted joints/entheses according to PsASon-Score13 and the most clinically involved joint/enthesis/tendon or the two most clinically involved joints/entheses/tendons (MIJET and 2MIJET).
Aims: ultrasound (US) diagnosis of enthesitis is burdened of low specificity, especially when it is performed in patients with psoriasis (PsO) but without clinical psoriatic arthritis (PsA), because of mechanical, dysmetabolic and age-related concurrent enthesopatic changes. We propose a novel US score to quantify the cortical-entheseal bone remodeling burden of several peripheral entheses, aiming to improve the specificity of US for PsA-related enthesitis, and to evaluate its diagnostic value in PsO patients with subsequent diagnosis of psoriatic arthritis (PsO/PsA).
Methods: clinical and US data of 119 consecutive patients with moderate/severe PsO and nonspecific musculoskeletal symptoms, were included in this retrospective study.
J Multidiscip Healthc
December 2024
Rheumatology Department, Unidade Local de Saúde de Santa Maria, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.
Purpose: Psoriatic arthritis (PsA) and psoriasis (Pso) are highly heterogeneous inflammatory diseases. Multidisciplinary approaches are associated with improved results in both musculoskeletal (MSK) and skin manifestations. We describe the experience and main diagnostic and therapeutic outcomes of one of the largest and longest-running Rheumatology/Dermatology multidisciplinary PsA Clinic.
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