AI Article Synopsis
- Metastasis is a major factor in poor cancer prognosis and the primary cause of cancer-related deaths, as tumor cells spread to distant sites through blood and lymph systems.
- Research is focused on using circulating tumor cells as a diagnostic tool and on experimental therapies that target these moving cancer cells.
- The review examines the pros and cons of these treatment strategies and their potential to help create new antimetastasis therapies.
Article Abstract
Metastasis contributes to poor prognosis in many types of cancer and is the leading cause of cancer-related deaths. Tumor cells metastasize to distant sites via the circulatory and lymphatic systems. In this review, we discuss the potential of circulating tumor cells for diagnosis and describe the experimental therapeutics that aim to target these disseminating cancer cells. We discuss the advantages and limitations of such strategies and how they may lead to the development of the next generation of antimetastasis treatments.
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| http://dx.doi.org/10.1146/annurev-bioeng-062117-120947 | DOI Listing |
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