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Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections.
Viruses
January 2025
Center for Virus-Host-Innate-Immunity, Institute for Infectious and Inflammatory Diseases, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
The type I interferon (IFN-I) response is a critical component of the immune defense against various viral pathogens, triggering the expression of hundreds of interferon-stimulated genes (ISGs). These ISGs encode proteins with diverse antiviral functions, targeting various stages of viral replication and restricting infection spread. Beyond their antiviral functions, ISGs and associated immune metabolites have emerged as promising broad-spectrum biomarkers that can differentiate viral infections from other conditions.
View Article and Find Full Text PDFGenotyping Genebank Collections: Strategic Approaches and Considerations for Optimal Collection Management.
Plants (Basel)
January 2025
United States Department of Agriculture Agricultural Research Service Small Grains and Potato Germplasm Research, Aberdeen, ID 83210, USA.
The maintenance of plant germplasm and its genetic diversity is critical to preserving and making it available for food security, so this invaluable diversity is not permanently lost due to population growth and development, climate change, or changing needs from the growers and/or the marketplace. There are numerous genebanks worldwide that serve to preserve valuable plant germplasm for humankind's future and to serve as a resource for research, breeding, and training. The United States Department of Agriculture (USDA) National Plant Germplasm System (NPGS) and the Consultative Group for International Agricultural Research (CGIAR) both have a network of plant germplasm collections scattered across varying geographical locations preserving genetic resources for the future.
View Article and Find Full Text PDFRisk Factors and Circulating Subtypes of spp. and in Hospitalized Children in Mozambique.
Microorganisms
January 2025
Unidade de Parasitologia Médica, Grupo de Parasitas Oportunistas/VIH e Outros Parasitas, Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal.
spp. and are important diarrheal agents in children in developing countries. Little is known about their molecular epidemiology; as such, the objective of this study was to determine the risk factors and genetic diversity of both parasites in diarrheal samples in Mozambique.
View Article and Find Full Text PDFCan Gut Microbiota Analysis Reveal Infection? Evidence from an Italian Cohort at Disease Onset.
Microorganisms
December 2024
Department of Laboratory and Infectious Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy.
A diverse and well-functioning gut microbiota normally serves as a protective shield against the invasion of harmful bacteria or the proliferation of opportunistic pathogens. infection (CDI) is predominantly associated with the overuse of antibiotics, resulting in a significant alteration in the gut's microbial balance. Unfortunately, the lack of global standardization does not allow for the identification of a set of biomarkers associated with the onset and progression of this disease.
View Article and Find Full Text PDFAssociation of Control Service Types with Aviation Medical Examination Results and Sick Leave in Air Traffic Controllers in Korea.
Healthcare (Basel)
January 2025
Department of Nursing, College of Nursing, The Eulji University of Korea, Uijeongbu 13135, Republic of Korea.
This study aimed to examine the association between the characteristics of air traffic controllers, their aviation medical examination results, and their sick leave, with the ultimate aim of promoting their health and contributing to the enhancement of aviation safety. : The subjects of this study were air traffic controllers affiliated with the Ministry of Land, Infrastructure, and Transport and the Airport Corporation in various regions of Korea. Data collection was conducted through a survey from 10 May 2023 to 10 December 2023.
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