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Effect of Digoxin vs Beta-Blockers on Left Atrial Strain for Heart Rate-Controlled Atrial Fibrillation: The DIGOBET-AF Randomized Clinical Trial.
Am J Cardiovasc Drugs
December 2024
Cardiology A Department, Research Laboratory LR12 SP 16 Fattouma Bourguiba University Hospital, University of Monastir, Monastir University, Rue du 1er juin 1955, 5000, Monastir, Tunisia.
Unlabelled: BACKGROUND AND OBJECTIVE: Left atrial strain (LAS) has prognostic value in patients with atrial fibrillation (AF). Consequently, therapies that improve LAS may help reduce AF-related adverse cardiac events. We aimed to compare how digoxin and bisoprolol modulate LAS in patients with AF being treated with rate control.
View Article and Find Full Text PDFResilience of primary healthcare facilities: Experiences from 16 European countries during the COVID-19 pandemic. A mixed-methods study conducted by EURIPA.
Adv Clin Exp Med
December 2024
European Rural and Isolated Practitioners Association (EURIPA), Paris, France.
Background: The role of primary healthcare (PHC) during a pandemic varies across European countries. The coronavirus disease 2019 (COVID-19) pandemic has altered the working practices of family medicine doctors and impacted the resilience of healthcare systems.
Objectives: This study aimed to examine European healthcare system responses to the pandemic, focusing on rural and urban differences.
Stem cells feel the pain.
Dev Cell
November 2024
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address:
Pain is a sensation that signals the presence of inflammation or injury. In this issue of Developmental Cell, Ben-Shaanan et al. show that beyond its sensory function, pain can activate hair follicle stem cells (HFSCs) by controlling their niche.
View Article and Find Full Text PDFThe Influence of High Body Mass Index (BMI > 35 kg/m) on Apixaban Plasma Concentration in Patients with Atrial Fibrillation.
Am J Cardiovasc Drugs
January 2025
Technion Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, 3109601, Israel.
Purpose: Apixaban, a direct oral anticoagulant is administered for stroke prevention in atrial fibrillation patients. Dosing adjustment is guided by renal function, age, and body weight. However, no data exist on its pharmacokinetics in patients with a body mass index (BMI) ≥ 35 kg/m.
View Article and Find Full Text PDFReal-World Evidence of Clinical Outcomes of the Use of the Adalimumab Biosimilar SB5 in Rheumatic and Gastrointestinal Immune-Mediated Inflammatory Diseases: 12-Month Data from the PERFUSE Study.
Drugs Real World Outcomes
December 2024
Biogen IDEC, Clinical Research, Biosimilars, Maidenhead, UK.
Article Synopsis
- The study focuses on SB5, an adalimumab biosimilar approved in Europe in 2017, and aims to gather real-world data on its usage and effectiveness in patients with various immune-mediated inflammatory diseases (IMIDs).
- Researchers analyzed clinical and healthcare claims data from the French national healthcare database to assess patient persistence on SB5 after 12 months.
- Among 911 patients treated with SB5, notable remission rates were observed at the 12-month mark, particularly in naïve patients, across various conditions such as rheumatoid arthritis and Crohn's disease, with all showing significant improvement from baseline.
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