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Gadolinium leakage into ocular structures as a marker in stroke: A retrospective analysis of the WAKE-UP trial.
Eur Stroke J
November 2024
Department of Neuroscience, KU Leuven, Leuven, Belgium.
Article Synopsis
- Blood-brain barrier disruption in acute ischemic stroke is linked to complications, with GLOS indicating issues in the blood-ocular barrier.
- In a study of WAKE-UP trial patients, 29% showed GLOS, significantly more than the 7% with HARM.
- GLOS presence was associated with factors like age, renal function, and white matter hyperintensity but did not correlate with hemorrhagic transformation or functional outcomes.
[Cognitive impairments associated with schizophrenic psychoses : Diagnostics, course and therapy].
Nervenarzt
November 2024
DZPG (Deutsches Zentrum für Psychische Gesundheit), Standort München/Augsburg, München, Deutschland.
Background: Longitudinal outcome studies confirm that the majority of patients with schizophrenic psychoses develop cognitive impairments associated with schizophrenia (CIAS).
Objective: To provide an overview of the epidemiology, diagnostics and evidence for various treatment options for CIAS.
Material And Methods: Literature review of the current level of evidence regarding the efficacy of different treatment strategies for CIAS.
[IEHT vs. Regular Treatment - Are there Differences between the Two forms of Treatment in the Retrospective Course with regard to Individual Objective and Subjective Outcome Variables?].
Psychiatr Prax
October 2024
Klinik für Psychiatrie und Psychotherapie, ZfP Südwürttemberg, Zwiefalten.
This retrospective follow-up study over one year (after discharge from the index treatment), compares the effects of inpatient-equivalent home treatment (IEHT) and regular psychiatric treatment using subjective and objective quality indicators. Using a 1:1 matching of cohorts (diagnosis, age, gender, number of previous treatments and severity of illness), 732 IEHT patients were assigned to a comparison group. Outcome data was taken from the routine data of the clinic database and the in-house basic documentation.
View Article and Find Full Text PDF[Fatal course of a fulminant gas gangrene of the right hemithorax].
Unfallchirurgie (Heidelb)
October 2024
Klinik für Unfallchirurgie und Orthopädie, Universitätsklinikum Knappschaftskrankenhaus Bochum, In der Schornau 23-25, 44892, Bochum, Deutschland.
Article Synopsis
- Gas gangrene is a rare but severe infection often caused by the pathogen Clostridium septicum, which can develop either from trauma or spontaneously, particularly in patients with conditions like occult colon carcinoma.
- Individuals with diabetes mellitus are at a higher risk for developing this infection, which has a high mortality rate of around 50%, even with aggressive treatment.
- Initial symptoms are vague, complicating early diagnosis, and treatment typically involves high-dose antibiotics, surgical removal of infected tissue, and sometimes hyperbaric oxygen therapy.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
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