Using Fura-2AM microfluorimetry, it was shown for the first time that phospholipase A inhibitors 4-bromophenacyl bromide and glucocorticosteroids prednisolone and dexamethasone attenuate Ca responses induced by neuroleptic trifluoperazine in macrophages. The results suggest the involvement of phospholipase A and arachidonic acid metabolism cascade in the effect of trifluoperazine on intracellular Ca concentration in macrophages.
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| http://dx.doi.org/10.1134/S1607672918010118 | DOI Listing |
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