AI Article Synopsis
- Antibody technologies are gaining traction in toxinology, leveraging advancements in immunology and synthetic biology to develop targeted therapies for neutralizing animal toxins.
- The review highlights various antibody formats, analyzing their therapeutic effectiveness, safety, and practical considerations for research and manufacturing.
- A growing trend is noted towards using human antibodies and camelid heavy-domain fragments, as they align well with the human immune system and are cost-effective for production.
Article Abstract
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to neutralize animal toxins. These different molecular formats each have their own therapeutic characteristics. In this review, we provide an overview of the advances made in the development of toxin-targeting antibodies, and discuss the benefits and drawbacks of different antibody formats in relation to their ability to neutralize toxins, pharmacokinetic features, propensity to cause adverse reactions, formulation, and expression for research and development (R&D) purposes and large-scale manufacturing. A research trend seems to be emerging towards the use of human antibody formats as well as camelid heavy-domain antibody fragments due to their compatibility with the human immune system, beneficial therapeutic properties, and the ability to manufacture these molecules cost-effectively.
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| http://dx.doi.org/10.1016/j.toxicon.2018.03.004 | DOI Listing |
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