Rugulactone is a natural product isolated from the plant . It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017073 | PMC |
| http://dx.doi.org/10.3390/molecules23030640 | DOI Listing |
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