In vivo and in vitro identification of Z-BOX C - a new bilirubin oxidation end product.

Org Biomol Chem

Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University, Lessingstrasse 8, D-07743 Jena, Germany.

Published: May 2018

AI Article Synopsis

  • - A new compound called Z-BOX C was discovered and analyzed, which is formed from bilirubin through specific intermediate compounds.
  • - This new compound was found in sick human bile samples using advanced techniques like liquid chromatography and mass spectrometry.
  • - The presence of Z-BOX C could be important for understanding liver issues and conditions like cerebral vasospasms (narrowing of blood vessels in the brain).

Article Abstract

A new bilirubin oxidation end product (BOX) was isolated and characterized. The formation of the so-called Z-BOX C proceeds from bilirubin via propentdyopents as intermediates. This BOX was detected in pathological human bile samples using liquid chromatography/mass spectrometry and has potential relevance for liver dysfunction and cerebral vasospasms.

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Source
http://dx.doi.org/10.1039/c8ob00164bDOI Listing

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