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http://dx.doi.org/10.1007/s13238-018-0522-y | DOI Listing |
J Mech Behav Biomed Mater
January 2025
School of Materials Science and Engineering, University of Jinan, Jinan, 250022, China. Electronic address:
Silicon nitride (Si₃N₄) ceramics exhibit excellent mechanical properties and biocompatibility, making them highly suitable for biomedical applications, particularly in implants. In this study, the mechanical properties and bioactivity of Si₃N₄ ceramics with varying amounts of Y₂O₃-Al₂O₃-SiO₂ sintering aids were investigated. Increasing the sintering additive content from 4 wt% to 8 wt% substantially improved the bulk density of the ceramics, leading to notable enhancements in mechanical properties.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Council for Geoscience, Private Bag X112, Pretoria, 0001, South Africa.
One-step high-pressure and high-temperature direct aqueous mineral carbonation of tailings derived from mining of Platinum Group Metals in South Africa requires a fundamental understanding of the reactivity of the most dominant mineral phases, i.e. pyroxene and plagioclase (66 wt.
View Article and Find Full Text PDFRadiat Res
January 2025
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Variable relative biological effectiveness (RBE) of carbon radiotherapy may be calculated using several models, including the microdosimetric kinetic model (MKM), stochastic MKM (SMKM), repair-misrepair-fixation (RMF) model, and local effect model I (LEM), which have not been thoroughly compared. In this work, we compared how these four models handle carbon beam fragmentation, providing insight into where model differences arise. Monoenergetic and spread-out Bragg peak carbon beams incident on a water phantom were simulated using Monte Carlo.
View Article and Find Full Text PDFViruses
December 2024
Department of Rehabilitation and Regenerative Medicine, College of Physicians and Surgeons, Columbia University, HHSC-1518, 701 W. 168th Street, New York, NY 10032, USA.
This study explores the effects of plant compounds on human papillomavirus (HPV)-induced W12 cervical precancer cells and bioelectric signaling. The aim is to identify effective phytochemicals, both individually and in combination, that can prevent and treat HPV infection and HPV associated cervical cancer. Phytochemicals were tested using growth inhibition, combination, gene expression, RT PCR, and molecular docking assays.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, 020956 Bucharest, Romania.
Aurora kinase B (AurB) is a pivotal regulator of mitosis, making it a compelling target for cancer therapy. Despite significant advances in protein kinase inhibitor development, there are currently no AurB inhibitors readily available for therapeutic use. This study introduces a machine learning-assisted drug repurposing framework integrating quantitative structure-activity relationship (QSAR) modeling, molecular fingerprints-based classification, molecular docking, and molecular dynamics (MD) simulations.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!