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Inflammatory Response of THP1 and U937 Cells: The RNAseq Approach.
Cells
December 2024
Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, Austria.
THP1 and U937 are monocytic cell lines that are common bioassays to reflect monocyte and macrophage activities in inflammation research. However, THP-1 is a human monocytic leukemia cell line, and U937 originates from pleural effusion of histiocytic lymphoma; thus, even though they serve as bioassay in inflammation research, their response to agonists is not identical. Consequently, there has yet to be a consensus about the panel of strongly regulated genes in THP1 and U937 cells representing the inflammatory response to LPS and IFNG.
View Article and Find Full Text PDFAltered levels of IFN-γ, IL-4, and IL-5 depend on the rs4986790 genotype in COPD smokers but not those exposed to biomass-burning smoke.
Front Immunol
August 2024
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Introduction: Chronic obstructive pulmonary disease (COPD) is associated with tobacco smoking and biomass-burning smoke exposure. Toll-like receptor 4 () single-nucleotide polymorphisms (SNPs) may contribute to its pathogenesis. The study aimed to assess the association of rs4986790 and rs4986791 in the gene in a Mexican mestizo population with COPD secondary to tobacco smoking (COPD-TS) and biomass-burning smoke (COPD-BBS) and to evaluate whether the genotypes of risk affect cytokine serum levels.
View Article and Find Full Text PDFValidation and functional follow-up of cervical cancer risk variants at the HLA locus.
HLA
August 2024
Department of Gynaecology, Comprehensive Cancer Center, Hannover Medical School, Hannover, Germany.
Cervical cancer is the fourth most common cancer in females. Genome-wide association studies (GWASs) have proposed cervical cancer susceptibility variants at the HLA locus on chromosome 6p21. To corroborate these findings and investigate their functional impact in cervical tissues and cell lines, we genotyped nine variants from cervical cancer GWASs (rs17190106, rs535777, rs1056429, rs2763979, rs143954678, rs113937848, rs3117027, rs3130214, and rs9477610) in a German hospital-based series of 1122 invasive cervical cancers, 1408 dysplasias, and 1196 healthy controls.
View Article and Find Full Text PDFCanine peripheral non-conventional TCRαβ CD4CD8α double-negative T cells show T helper 2-like and regulatory properties.
Front Immunol
June 2024
Institute of Immunology, Center for Biotechnology and Biomedicine, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany.
The dog is an important companion animal and also serves as model species for human diseases. Given the central role of T cells in immune responses, a basic understanding of canine conventional T cell receptor (TCR)αβ T cells, comprising CD4 single-positive (sp) T helper (Th) and CD8α sp cytotoxic T cell subsets, is available. However, characterization of canine non-conventional TCRαβ CD4CD8α double-positive (dp) and TCRαβ CD4CD8α double-negative (dn) T cells is limited.
View Article and Find Full Text PDFChitosan-Loaded and Potentiate Antibacterial, Antioxidant, and Immunomodulatory Activities against Extensive Drug-Resistant and Vancomycin-Resistant : In Vitro and In Vivo Approaches.
Antioxidants (Basel)
March 2024
Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
Antimicrobial resistance poses considerable issues for current clinical care, so the modified use of antimicrobial agents and public health initiatives, coupled with new antimicrobial approaches, may help to minimize the impact of multidrug-resistant (MDR) bacteria in the future. This study aimed to evaluate the antimicrobial, antioxidant, and immunomodulatory activities of , , and their chitosan nanocomposites against extensive drug-resistant (XDR) and vancomycin-resistant (VRSA) using both in vitro and in vivo assays. The in vitro antimicrobial susceptibilities of and VRSA strains revealed 100% sensitivity to imipenem (100%).
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