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Study of the pharmacokinetics of polymerized porcine hemoglobin (pPolyHb). | LitMetric

AI Article Synopsis

  • Polymerized porcine hemoglobin (pPolyHb) is being investigated as a potential substitute for red blood cells in medical applications, focusing on its safety and effectiveness.
  • The study analyzed pharmacokinetic parameters in various animal models, indicating that pPolyHb behaves in accordance with linear pharmacokinetics, particularly in rats.
  • Results showed a longer and more stable half-life for pPolyHb under normal conditions, but this could decrease in clinical scenarios like trauma, providing valuable insights for dosage and administration in future treatments.

Article Abstract

Polymerized porcine hemoglobin (pPolyHb), a kind of glutaraldehyde-polymerized haemoglobin-based oxygen carrier, was developed as a potential red blood substitute for clinical applications. Assessment of its absorption, distribution, and metabolism is a major determinant of its safety and efficacy. In this study, a series of pharmacokinetic parameters of pPolyHb were measured and calculated in different animal models, such as the top-load model, the 50% exchange transfusion model and the haemorrhagic shock model. The results showed that the kinetic process of pPolyHb in rats conforms to the laws of linear pharmacokinetics in vivo. The half-life of pPolyHb was superior and more stable under non-pathological conditions, but in clinical situations such as trauma and anaemia, the half-life of pPolyHb may decline. The study of clearance (CL) and the apparent volume of distribution (Vd) of pPolyHb in these three different animal models demonstrated longer residence and a predominant, targeted role of pPolyHb with little accumulation in tissues. Through this study, the superior pharmacokinetic characteristics of pPolyHb have been proved and will aid in the determination of a reasonable dosing regimen and administration interval in clinical situations.

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Source
http://dx.doi.org/10.1080/21691401.2018.1446020DOI Listing

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