Arf levels are tightly regulated in cells and correlate with the level of ribosome biogenesis and proliferative status of cells. Through multivalent interactions with NPM1 - a regulator of ribosome biogenesis, and Mdm2 - a regulator of cellular fate, Arf integrates within the nucleolar matrix, altering its structure, dynamics and function and therefore modulates the cell cycle.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965676 | PMC |
| http://dx.doi.org/10.1111/febs.14407 | DOI Listing |
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