Trial Design: Three feeding regimens-centrally produced ready-to-use therapeutic food, locally produced ready-to-use therapeutic food, and augmented, energy-dense, home-prepared food-were provided in a community setting for children with severe acute malnutrition (SAM) in the age group of 6-59 months in an individually randomised multicentre trial that enrolled 906 children. Foods, counselling, feeding support and treatment for mild illnesses were provided until recovery or 16 weeks.
Methods: Costs were estimated for 371 children enrolled in Delhi in a semiurban location after active survey and identification, enrolment, diagnosis and treatment for mild illnesses, and finally treatment with one of the three regimens, both under the research and government setting. Direct costs were estimated for human resources using a price times quantity approach, based on their salaries and average time taken for each activity. The cost per week per child for food, medicines and other consumables was estimated based on the total expenditure over the period and children covered. Indirect costs for programme management including training, transport, non-consumables, infrastructure and equipment were estimated per week per child based on total expenditures for research study and making suitable adjustments for estimations under government setting.
Results: No significant difference in costs was found across the three regimens per covered or per treated child. The average cost per treated child in the government setting was estimated at US$56 (<3500 rupees).
Conclusion: Home-based management of SAM with a locally produced ready-to-use therapeutic food is feasible, acceptable, affordable and very cost-effective in terms of the disability-adjusted life years saved and gross national income per capita of the country. The treatment of SAM at home needs serious attention and integration into the existing health system, along with actions to prevent SAM.
Trial Registration Number: NCT01705769; Pre-results.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841493 | PMC |
http://dx.doi.org/10.1136/bmjgh-2017-000702 | DOI Listing |
Objective: To increase the number of episodes of vitamin D teaching in the primary care setting for parents of human milk-fed infants and to explore pediatric clinicians' knowledge of vitamin D supplementation in human milk-fed infants and their perception of project intervention usefulness.
Design: Quality improvement project using a quasi-experimental, pretest-posttest design.
Setting/local Problem: Despite recommendations from the American Academy of Pediatrics, vitamin D supplementation adherence rates for human milk-fed infants remain low.
Women Birth
January 2025
School of Nursing, Midwifery and Social Work, The University of Queensland, Whitty Building, Mater Hospital Campus, South Brisbane, Australia. Electronic address:
Background: Despite breastfeeding being widely accepted as the optimal feeding method for infants many women do not meet their breastfeeding goals or continue to breastfeed as long as recommended. Continuation of exclusive breastfeeding is multifactorial, with midwifery support during the postnatal period considered to be an important component. However, little is known about how women receive this support from midwives across varying models of care.
View Article and Find Full Text PDFClin Oral Investig
January 2025
Department of Periodontology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, 310009, P. R. China.
Aims: Our goal is to perform a meta-analysis to investigate the risk of periodontitis associated with specific dietary patterns.
Methods: We employed the PRISMA methodology in a meta-analysis to examine the correlation between dietary patterns and the risk of periodontitis. We systematically searched three online databases from inception to November 2024 to identify relevant studies.
Alzheimers Dement
December 2024
School of Pharmacy, Chapman University, Irvine, CA, USA.
Background: Chronic heavy alcohol drinking may be a modifiable risk factor for Alzheimer's disease (AD), but studies in rodent AD models more closely mimic chronic moderate alcohol drinking in humans and largely focus on the brain. The role of the liver, which is significantly impacted by chronic heavy alcohol intake, in driving brain changes in alcohol-dependent AD remains unexplored. Our study using intragastric-ethanol feeding, which mimics chronic heavy alcohol intake in humans, in C57BL/6J mice showed significant AD-relevant changes in the brain and liver.
View Article and Find Full Text PDFBackground: Predicting decline over the course of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), especially on relatively short time frames, is vital for appropriate treatment planning and to tailor patient and support systems' expectations. The current study tested if a functional upper limb motor learning task could predict one-year change in cognition and daily function.
Method: Cognitively unimpaired (n = 61), MCI (n = 35), and AD (32) older subjects (age: 74.
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