Dehydroacetic acid is a common pyrone derivative used commercially as an antibacterial and antifungal agent. Based on the synthesis of dehydroacetic acid () from -hydroxysuccinimdyl acetoacetate, a novel series of enamine-based derivatives were synthesised in order to improve the antibacterial activity of dehydroacetic acid. The antibacterial activities of the synthesised analogues were evaluated against and . Derivative (N-Ph) was identified as the most potent inhibitor of growth. Overall, derivative (N-Me) showed the best broad-spectrum activity with five-fold greater minimum inhibitory concentration and 11-fold greater minimum biocidal concentration against when compared to dehydroacetic acid, in addition to improved antibacterial activity against .
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| http://dx.doi.org/10.1007/s00044-017-2110-8 | DOI Listing |
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