Introduction: Palmoplantar lesions of lichen planus (LP) are uncommon and may not always have classical clinical features of LP. A variety of morphological types has been described in literature.
Aim And Objectives: The aim was to study and classify the clinical variants into distinct easily recognisable categories for quick recognition and early treatment initiation.
Methods: All patients diagnosed with LP over a period of 5 years were evaluated for palmoplantar lesions in our hospital. The clinical and histopathological features of the palmoplantar lesions were then studied.
Results: Out of 424 patients of LP, 55 (12.9%) had palmoplantar lesions. Histopathology was consistent or at least compatible with LP in 44/55 patients. For the purpose of assessment, only patients with histopathology consistent with LP were included ( = 44) in the study. Just over half of the patients were male, with most patients (43.2%) having had LP lesions elsewhere for 6 months before palmoplantar lesions were noticed. Soles were more frequently involved than palms. The sites most often involved were the centre of the palms (45.2%), and the instep of the soles (63.9%). The predominant morphological presentation was psoriasiform (47.7%). One patient had ulcerative lesions of LP on both his soles which is a very rare variant. Notably, nearly half of the patients (20/44) had mucosal (mostly oral) lesions characteristic of LP. This was significant as typical oral lesions of LP help in identifying palmoplantar lesions that do not have classical lichenoid morphology.
Conclusion: LP lesions on palms and soles need to be identified keeping a high index of suspicion and differentiated from other papulosquamous conditions so that specific treatment can be initiated early.
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http://dx.doi.org/10.4103/ijd.IJD_161_17 | DOI Listing |
Am J Transl Res
November 2024
Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510120, Guangdong, China.
Background: Sulfur cream is reported to relieve itching and treat skin diseases caused by bacterial, fungal, and scabies infections. However, there is limited data on the efficacy of sulfur cream blowing and parching combined with compound ketoconazole ointment (ketoconazole, clobetasol propionate, and neomycin sulfate) in curing palmoplantar keratotic eczema. This prospective study proposed to investigate the clinical efficacy of sulfur cream on people who suffer with palmoplantar keratotic eczema.
View Article and Find Full Text PDFCureus
November 2024
Dermatopathology, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, SVN.
Keratoelastoidosis marginalis of the hands (KEMH) is an acquired form of marginal papular keratoderma, characterized by thickened keratotic plaques predominantly affecting the lateral side of the index finger and the medial side of the thumb. It is often associated with chronic sun exposure and trauma, usually affecting older individuals. Due to clinical similarities with other palmoplantar keratodermas, differential diagnosis is essential for effective treatment management.
View Article and Find Full Text PDFJ Dermatol
December 2024
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Hereditary palmoplantar keratoderma (hPPK) comprises a clinical and heterogeneous group of skin disorders characterized by hyperkeratosis of the palms and soles. Variants of SERPINA12 have been implicated in autosomal recessive diffuse hPPK, which shares similarities with Nagashima-type PPK due to biallelic variants in SERPINB7. To date, seven SERPINA12 variants have been found in 11 patients with biallelic SERPINA12 variants worldwide.
View Article and Find Full Text PDFJAAD Case Rep
December 2024
Department of Dermatology, SUNY Downstate Health Sciences University, Brooklyn, New York.
J Dermatolog Treat
December 2024
Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China.
Aim: SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a rare autoimmune disorder characterized by typical cutaneous lesions (palmoplantar pustulosis and eruptive acne) and osteoarticular symptoms (aseptic osteomyelitis and joint inflammation). This study aims to evaluate the therapeutic efficacy and safety of Janus kinase 1 (JAK1) inhibitor abrocitinib in patients with SAPHO syndrome.
Methods: We presented a patient with SAPHO syndrome with accelerated disease progression who did not respond to traditional therapies.
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