AI Article Synopsis
- Chronic morphine treatment was found to worsen cognitive function in mice infected with LP-BM5/murine AIDS (MAIDS), indicating that opioid use can negatively impact brain health in HIV/AIDS patients.
- Research showed that morphine reduced pro-inflammatory factors and cognitive performance, leading to higher viral load in the hippocampus and a weaker immune response.
- In contrast, morphine decreased viral load in the striatum while increasing type 1 interferon (IFN-α) expression, suggesting that the effects of opioids vary by brain region.
Article Abstract
Opioid use accelerates neurocognitive impairment in HIV/AIDS patients. We assessed the effect of chronic morphine treatment and LP-BM5/murine AIDS (MAIDS) infection on cognition, cytokine production, and type 1 interferon (IFN) expression in the murine CNS. Morphine treatment decreased expression of pro-inflammatory factors (CCL5, iNOS) and reduced cognitive performance in LP-BM5-infected mice, correlating to increased hippocampal viral load and a blunted type 1 IFN response. In the striatum, morphine reduced viral load while increasing IFN-α RNA expression. Our results suggest that differentially regulated type 1 IFN responses may contribute to distinct regional outcomes in the hippocampus and striatum in LP-BM5/MAIDS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915896 | PMC |
| http://dx.doi.org/10.1016/j.jneuroim.2018.02.017 | DOI Listing |
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