Glasses with composition 55SiO-10KO-(35-x)CaO-xMgO (x = 5, 10, 15 up to 35) were prepared via conventional melt-quench technique. The glasses were converted to glass-ceramics by controlled heat-treatment at 850 °C. Higher content of MgO instead of CaO prevents the devitrification of the glasses. The in-vitro bioactivity of the glasses/glass-ceramics was evaluated in simulated body fluid (SBF). Glasses exhibited better bioactivity than the glass-ceramics. The weight loss and ions leaching profiles (especially potassium ions) of the samples played crucial role in formation of hydroxyapatite layer and its morphology. Hydroxyapatite had Ca/P ratio close to that for natural bone. However, it could not crystallize within experimental time and exhibited amorphous nature in X-ray diffraction. Microhardness of the glasses/glass-ceramics before and after immersion in SBF is also given. Microbial tests reveal that these glasses/glass-ceramics are effective in inhibiting the growth of fungi and do not affect the normal functioning of the antimicrobial drugs.
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