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Introduction: We investigated the analytical performance, outlier rate, carryover and reference interval of the Beckman Coulter Access hsTnI in detail and compared it with historical and other commercial assays.
Materials And Methods: We compared the imprecision, detection capability, analytical sensitivity, outlier rate and carryover against two previous Access AccuTnI assay versions. We established the reference interval with stored samples from a previous study and compared the concordances and variances with the Access AccuTnI+3 as well as with two commercial assays.
Results: The Access hsTnI had excellent analytical sensitivity with the calibration slope 5.6 times steeper than the Access AccuTnI+3. The detection capability was markedly improved with the SD of the blank 0.18-0.20 ng/L, LoB 0.29-0.33 ng/L and LoD 0.58-0.69 ng/L. All the reference interval samples had a result above the LoB value. At a mean concentration of 2.83 ng/L the SD was 0.28 ng/L (CV 9.8%). Carryover (0.005%) and outlier (0.046%) rates were similar to the Access AccuTnI+3. The combined male and female 99th percentile reference interval was 18.2 ng/L (90% CI 13.2-21.1 ng/L). Concordance amongst the assays was poor with only 16.7%, 19.6% and 15.2% of samples identified by all 4 assays as above the 99th, 97.5th and 95th percentiles. Analytical imprecision was a minor contributor to the observed variances between assays.
Conclusion: The Beckman Coulter Access hsTnI assay has excellent analytical sensitivity and precision characteristics close to zero. This allows cTnI measurement in all healthy individuals and the capability to identify numerically small differences between serial samples as statistically significant. Concordance in healthy individuals remains poor amongst assays.
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http://dx.doi.org/10.1016/j.clinbiochem.2018.03.003 | DOI Listing |
Gastroenterology
December 2024
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California.
Description: Gastric cancer (GC) is a leading cause of preventable cancer and mortality in certain US populations. The most impactful way to reduce GC mortality is via primary prevention, namely Helicobacter pylori eradication, and secondary prevention, namely endoscopic screening and surveillance of precancerous conditions, such as gastric intestinal metaplasia (GIM). An emerging body of evidence supports the possible impact of these strategies on GC incidence and mortality in identifiable high-risk populations in the United States.
View Article and Find Full Text PDFJ Dairy Sci
December 2024
Department of Animal Science, Michigan State University, East Lansing, MI, USA, 48824. Electronic address:
Meta-analyses have become increasingly common, providing meaningful summaries of cumulative knowledge in the dairy science literature. Some of the corresponding meta-analytic techniques have been developed by knowledgeable dairy scientists, some of which pre-date tractable likelihood-based random or mixed effects model meta-analytic techniques and associated software developed by statisticians. This review compares various meta-analytic techniques on aggregate data (i.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
December 2024
Department of Cardiovascular Medicine, Zheng Zhou Cardiovascular Hospital, The 7th People's Hospital of Zheng Zhou, No. 17, Jingnan Fifth Road, Huizhuang Development Zone, Zhengzhou, Henan, 450000, China.
Background: Heart failure (HF) and atrial fibrillation (AF) usually coexist and are associated with a poorer prognosis. This study aimed to develop a model to predict in-hospital mortality in patients with HF combined with AF.
Methods: Patients with HF and AF were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database from 2008 to 2019.
J Neurointerv Surg
December 2024
Department of Neurology, Jinling Hospital, Nanjing Medical University, Nanjing, China
Background: Despite successful recanalization via mechanical thrombectomy (MT), only half of acute ischemic stroke (AIS) patients achieve functional independence. Post-MT hemodynamic features are insufficiently investigated, and the lack of bilateral comparisons limits individual assessment. Therefore, we aimed to explore how individualized hemodynamic features affect functional outcomes using quantitative digital subtraction angiography (Q-DSA).
View Article and Find Full Text PDFObjectives: The objective of the study was to investigate the prevalence of hyperthyroidism in Spain, including its geographical distribution and prevalence across different age groups.
Methods: A cross-sectional study was conducted. Samples submitted to a reference laboratory to evaluate serum total thyroxine concentration (TT4) during a 3-year period were evaluated (n = 27,888).
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