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Longitudinal stability and predictive value of socio/emotional/behavioral screening in an Outpatient Pediatric Network.
Acad Pediatr
December 2024
Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
Background: In 2022, the American Academy of Pediatrics recommended annual social/emotional/behavioral (SEB) screening at preventive pediatric visits. Numerous SEB screeners have considerable empirical support for children of all ages. However, few studies inform the longitudinal use of SEB screeners in pediatrics.
View Article and Find Full Text PDFUSP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer.
Oncogene
December 2024
Protein Stability and Cancer Group, University of Wuerzburg, Department of Biochemistry and Molecular Biology, Wuerzburg, Germany.
The contribution of deubiquitylating enzymes (DUBs) to β-Catenin stabilization in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, and by using an unbiassed screen, we discovered that the DUB USP10 stabilizes β-Catenin specifically in APC-truncated CRC in vitro and in vivo. Mechanistic studies, including in vitro binding together with computational modelling, revealed that USP10 binding to β-Catenin is mediated via the unstructured N-terminus of USP10 and is outcompeted by intact APC, favouring β-catenin degradation.
View Article and Find Full Text PDFBlood transcriptome profiling reveals distinct gene networks induced by mRNA vaccination against COVID-19.
Eur J Immunol
November 2024
Institute of Immunology, Hannover Medical School, Hannover, Germany.
Article Synopsis
- mRNA vaccines have proven effective against COVID-19 and hold promise for other uses, as they change the activity of certain genes in the body post-vaccination.
- This study analyzed blood transcriptomes before and after mRNA vaccination to identify gene networks that are either upregulated or downregulated based on the response to the vaccine.
- The research found that specific gene networks related to immune response and processes like viral defense can be targeted for improving future vaccine designs, potentially enhancing their effectiveness.
Longitudinal interactions between maternal depression symptoms and familial stressful life events on child anxiety symptoms at 5 years of age.
Infancy
December 2024
Boston Children's Hospital (Division of Developmental Medicine), Harvard Medical School (Department of Pediatrics), Boston, Massachusetts, USA.
In the current study we identified salient parental factors for child anxiety symptoms by considering the role of stressful life events, maternal anxiety symptoms, maternal depressive symptoms, and maternal neuroticism. Families (N = 399) in an urban area in the United States were participants in a longitudinal study beginning in infancy. Mothers completed measures of stressful life events (Revised Life Events Questionnaire at all visits), maternal anxiety and depressive symptoms (State-Trait Anxiety Inventory and Beck Depression Inventory, respectively, at infancy between 5 and 12 months, at 2 years, and at 3 years), maternal neuroticism (NEO Five-Factor Inventory at infancy), and child anxiety symptoms (Child Behavior Checklist 1.
View Article and Find Full Text PDFGender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals.
BMC Med
September 2024
Institute of Forensic Psychiatry and Sex Research, Center for Translational Neuro- and Behavioral Sciences, University of Duisburg-Essen, Alfredstr. 68-72, Essen, 45130, Germany.
Article Synopsis
- This study investigates how gender-affirming hormonal therapy (GAHT) affects gut microbiota in transgender individuals, focusing on the nuanced impact of sex steroids on microbial changes.
- Thirty-six participants (17 trans women and 19 trans men) were analyzed for shifts in gut microbiota before and after 12 weeks of GAHT, using advanced sequencing techniques.
- Findings revealed significant changes in specific gut bacteria related to affirmed gender, indicating that GAHT leads to distinct microbial profiles and may affect health outcomes for trans men and women.
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