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Pharmacokinetics of amlodipine besylate at delivery and during lactation. | LitMetric

AI Article Synopsis

  • * Sixteen women were observed, with blood samples collected at delivery and postpartum to measure amlodipine levels, showing detectable amounts in umbilical cord blood but none in breast milk or infant plasma.
  • * Results suggest that while amlodipine can cross the placenta, it doesn't transfer to breast milk or affect infants shortly after birth, indicating it may be safe for treating chronic hypertension during pregnancy.

Article Abstract

Background: Amlodipine is rarely used in the treatment of pregnant hypertensive women due to limited pharmacokinetic data during pregnancy and the postpartum period.

Objective: To evaluate the pharmacokinetics of amlodipine besylate in the peri-partum period including quantities of placental passage, breast milk excretion and infant exposure.

Study Design: This was a prospective study of pregnant women who were prescribed 5 mg of amlodipine daily for treatment of chronic hypertension and delivered at term. Cord and maternal blood samples were collected at delivery. On postpartum day 2, six paired maternal plasma and breast milk samples were obtained at 4, 6, 8, 12, 15 and 24 h following amlodipine dosing. Infant plasma samples were collected 24-48 h after delivery. All samples were analyzed for amlodipine concentration. A one compartment, first-order model was used to calculate pharmacokinetic estimates for maternal plasma.

Results: Of the 16 patients enrolled in the study, 11 had cord blood and maternal serum collected at delivery, of which only 6 produced sufficient breast milk for sampling. Amlodipine was detected in infant cord blood plasma with a mean concentration of 0.49 ± 0.29 ng/mL compared to mean maternal serum level of 1.27 ± 0.84 ng/mL. Amlodipine concentrations in both in breast milk and infant plasma were undetectable at the lower limit of assay detection (<0.1 ng/mL). In the immediate postpartum period, the amlodipine elimination half-life was 13.7 ± 4.9 h, the area under the curve was 53.4 ± 19.8 ng*h/mL and the peak concentration was 2.0 ± 1.0 ng/mL.

Conclusions: Amlodipine does cross the placenta in measurable quantities, but is not detected in breast milk or infant plasma at 24-48 h of life indicating that it is likely safe to use during the peripartum period.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846630PMC
http://dx.doi.org/10.1016/j.preghy.2018.01.002DOI Listing

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