AI Article Synopsis
- A new probe for detecting peroxynitrite (ONOO) was developed using a specific chemical structure based on benzothiazole hydrazone.
- This probe shows weak fluorescence until it interacts with ONOO, which triggers a reaction that enhances its fluorescence significantly.
- It is highly selective, sensitive with a low detection limit, and can quickly identify ONOO in just 60 seconds, making it useful for imaging in living cells.
Article Abstract
A simple structured reaction-based probe for peroxynitrite (ONOO) was developed by using benzothiazole hydrazone base of the excited-state intramolecular proton transfer (ESIPT) dye. It was constructed from 2-hydrazinylpyridine and 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde which possesses itself weak fluorescence and displayed prominent fluorescence response towards ONOO by oxidizes the C=N bond to an aldehyde in aqueous solution. The probe exhibited excellent selectivity and high sensivity towards ONOO with a low dectection limit of 5.8 × 10 M in physiological condition. Moreover, the probe could realize fast recognition to ONOO in as short as 60 s. In addition, the probe was also successfully used for living cell imaging.
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| http://dx.doi.org/10.1016/j.aca.2018.01.046 | DOI Listing |
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