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Exploring the Link Between Mucin 2 and Weaning Stress-Related Diarrhoea in Piglets.
Int J Mol Sci
January 2025
College of Animal Science and Technology, Northeast Agricultural University, No. 600 Changjiang Road, Xiangfang District, Harbin 150030, China.
To explore the relationship between intestinal mucin 2 () and weaning-induced diarrhoea in piglets, we analysed and piglets. The piglets were divided into a healthy weaned group, a weaned diarrhoea group, and a healthy unweaned control group. Intestinal tissues were collected, and goblet cell numbers, sizes, and degrees of intestinal injury were observed and recorded.
View Article and Find Full Text PDFDevelopment of a nasal spray based on cyclodextrin/hydrophobically-modified hydroxypropyl-methyl cellulose for the prevention of viral respiratory infections.
Int J Biol Macromol
January 2025
Department of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy. Electronic address:
The work aims to develop mucoadhesive and thermo-responsive in situ gelling systems, using hydrophobically-modified hydroxypropyl-methyl cellulose (Sangelose, SG) and beta-cyclodextrin (β-CD) derivatives, for preventing viral respiratory infections. Eight SG/CD systems with varying CD concentrations were evaluated for rheological properties, mucoadhesiveness, spreadability and sprayability via nasal devices; cytotoxicity was in vitro investigated on reconstituted nasal epithelia. Additionally, droplet size distribution and spray deposition were assessed for the most promising systems.
View Article and Find Full Text PDFAllergic Rhinitis and Its Associated Co-Morbidities Among Patients Attending the ENT Department at Kilimanjaro Christian Medical Center in Northern Tanzania: Cross-Sectional Study.
Immun Inflamm Dis
January 2025
Department of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Introduction: Allergic rhinitis is the specific inflammation against allergen by immune defense cells on the nasal mucosa, which can lead to chronic nasal symptoms such as sneezing, itching, runny nose, and nasal congestion. It is associated with high morbidity including sinusitis, asthma, otitis media, hypertrophied inferior turbinate, and nasal polyps. Despite its complications, it remains poorly recognized and tracked.
View Article and Find Full Text PDFAssociation of Menopause and Rhinitis Among Adult Women in the United States: Findings from the All of Us Research Program.
Laryngoscope
January 2025
Department of Otolaryngology, College of Medicine, University of Illinois Chicago, Chicago, Illinois, U.S.A.
Objective: The inflammatory role of female hormones has been garnering increased attention in the literature. Studies suggest a link between estrogen and inflammatory conditions of the airways and nasal mucosa. However, there remains a paucity of literature regarding the associations of hormones with rhinitis.
View Article and Find Full Text PDFIntranasal Immunization with DNA Vaccine HA-CCL19/Polyethylenimine/Chitosan Composite Provides Immune Protection Against H7N9 Infection.
Vaccines (Basel)
December 2024
Department of Basic Research, Ab & B Bio-Tech Co., Ltd. JS, Taizhou 225300, China.
Background/objectives: The H7N9 avian influenza virus (AIV) constitutes a novel subtype of influenza virus that has emerged within the past decade. Empirical studies have demonstrated that H7N9 AIV holds the potential to trigger a human pandemic. Vaccines constitute the sole armament available to humanity in combating influenza epidemics.
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